Percutaneous radiofrequency ablation of hepatocellular carcinoma: Of histologic grade on therapeutic results

Hyun Kim Seong, Hyo K. Lim, Dongil Choi, Jae Lee Won, Hoon Kim Seung, Min Ju Kim, Kyo Kim Chan, Hwan Jeon Yong, Jongmee Lee, Hyunchul Rhim

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of our study was to assess the therapeutic results of radiofrequency ablation of hepatocellular carcinoma (HCC) based on the histologic grades of the tumors. SUBJECTS AMD METHODS. Between April 1999 and December 2003, 95 patients with nodular HCC were treated with percutaneous radiofrequency ablation. All tumors were histologically proven by sonography-guided percutaneous biopsy and were classified as Edmondson-Steiner grade IHCC (n = 38) (mean, 2.3 cm) (group 1), grade IIHCC (n = 50) (mean, 2.4 cm) (group 2), or grade III HCC (n = 7) (mean, 2.8 cm) (group 3). All patients underwent contrast-enhanced three-phase helical CT examination before and after radiofrequency ablation. After retrospective review of the medical records and follow-up CT examinations, the rates of technique effectiveness, local tumor progression, cumulative survival, and cancer-free survival using a Kaplan-Meier method were calculated and compared among the groups. RESULTS. Technique effectiveness rates in groups 1, 2, and 3 were 87% (27/31), 71% (30/42), and 43% (3/7), respectively, with statistical significance (p = 0.032). Local tumor progression rates in groups 1,2, and 3 were 16% (5/31), 36% (15/42), and 71% (5/7), respectively, with statistical significance (p = 0.013). Five-year cumulative survival rates in groups 1, 2, and 3 were 71%, 44%, and 43%, respectively, with no statistical significance (p > 0.05). Four-year cancer-free survival rates in groups 1, 2, and 3 were 39%, 10%, and 0%, respectively (p < 0.05 for groups 1 vs 2; p > 0.05 for groups 1 vs 3 and groups 2 vs 3). CONCLUSION. The histologic grade of HCC is an important factor influencing therapeutic results with survival after radiofrequency ablation.

Original languageEnglish
JournalAmerican Journal of Roentgenology
Volume186
Issue number5 SUPPL.
DOIs
Publication statusPublished - 2006 May 1
Externally publishedYes

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Hepatocellular Carcinoma
Neoplasms
Survival
Therapeutics
Survival Rate
Spiral Computed Tomography
Medical Records
Ultrasonography
Biopsy

Keywords

  • Ablation
  • Hepatocellular carcinoma
  • Histologic grade
  • Radiofrequency

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Percutaneous radiofrequency ablation of hepatocellular carcinoma : Of histologic grade on therapeutic results. / Seong, Hyun Kim; Lim, Hyo K.; Choi, Dongil; Won, Jae Lee; Seung, Hoon Kim; Kim, Min Ju; Chan, Kyo Kim; Yong, Hwan Jeon; Lee, Jongmee; Rhim, Hyunchul.

In: American Journal of Roentgenology, Vol. 186, No. 5 SUPPL., 01.05.2006.

Research output: Contribution to journalArticle

Seong, Hyun Kim ; Lim, Hyo K. ; Choi, Dongil ; Won, Jae Lee ; Seung, Hoon Kim ; Kim, Min Ju ; Chan, Kyo Kim ; Yong, Hwan Jeon ; Lee, Jongmee ; Rhim, Hyunchul. / Percutaneous radiofrequency ablation of hepatocellular carcinoma : Of histologic grade on therapeutic results. In: American Journal of Roentgenology. 2006 ; Vol. 186, No. 5 SUPPL.
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abstract = "OBJECTIVE. The purpose of our study was to assess the therapeutic results of radiofrequency ablation of hepatocellular carcinoma (HCC) based on the histologic grades of the tumors. SUBJECTS AMD METHODS. Between April 1999 and December 2003, 95 patients with nodular HCC were treated with percutaneous radiofrequency ablation. All tumors were histologically proven by sonography-guided percutaneous biopsy and were classified as Edmondson-Steiner grade IHCC (n = 38) (mean, 2.3 cm) (group 1), grade IIHCC (n = 50) (mean, 2.4 cm) (group 2), or grade III HCC (n = 7) (mean, 2.8 cm) (group 3). All patients underwent contrast-enhanced three-phase helical CT examination before and after radiofrequency ablation. After retrospective review of the medical records and follow-up CT examinations, the rates of technique effectiveness, local tumor progression, cumulative survival, and cancer-free survival using a Kaplan-Meier method were calculated and compared among the groups. RESULTS. Technique effectiveness rates in groups 1, 2, and 3 were 87{\%} (27/31), 71{\%} (30/42), and 43{\%} (3/7), respectively, with statistical significance (p = 0.032). Local tumor progression rates in groups 1,2, and 3 were 16{\%} (5/31), 36{\%} (15/42), and 71{\%} (5/7), respectively, with statistical significance (p = 0.013). Five-year cumulative survival rates in groups 1, 2, and 3 were 71{\%}, 44{\%}, and 43{\%}, respectively, with no statistical significance (p > 0.05). Four-year cancer-free survival rates in groups 1, 2, and 3 were 39{\%}, 10{\%}, and 0{\%}, respectively (p < 0.05 for groups 1 vs 2; p > 0.05 for groups 1 vs 3 and groups 2 vs 3). CONCLUSION. The histologic grade of HCC is an important factor influencing therapeutic results with survival after radiofrequency ablation.",
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AU - Seong, Hyun Kim

AU - Lim, Hyo K.

AU - Choi, Dongil

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AU - Seung, Hoon Kim

AU - Kim, Min Ju

AU - Chan, Kyo Kim

AU - Yong, Hwan Jeon

AU - Lee, Jongmee

AU - Rhim, Hyunchul

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N2 - OBJECTIVE. The purpose of our study was to assess the therapeutic results of radiofrequency ablation of hepatocellular carcinoma (HCC) based on the histologic grades of the tumors. SUBJECTS AMD METHODS. Between April 1999 and December 2003, 95 patients with nodular HCC were treated with percutaneous radiofrequency ablation. All tumors were histologically proven by sonography-guided percutaneous biopsy and were classified as Edmondson-Steiner grade IHCC (n = 38) (mean, 2.3 cm) (group 1), grade IIHCC (n = 50) (mean, 2.4 cm) (group 2), or grade III HCC (n = 7) (mean, 2.8 cm) (group 3). All patients underwent contrast-enhanced three-phase helical CT examination before and after radiofrequency ablation. After retrospective review of the medical records and follow-up CT examinations, the rates of technique effectiveness, local tumor progression, cumulative survival, and cancer-free survival using a Kaplan-Meier method were calculated and compared among the groups. RESULTS. Technique effectiveness rates in groups 1, 2, and 3 were 87% (27/31), 71% (30/42), and 43% (3/7), respectively, with statistical significance (p = 0.032). Local tumor progression rates in groups 1,2, and 3 were 16% (5/31), 36% (15/42), and 71% (5/7), respectively, with statistical significance (p = 0.013). Five-year cumulative survival rates in groups 1, 2, and 3 were 71%, 44%, and 43%, respectively, with no statistical significance (p > 0.05). Four-year cancer-free survival rates in groups 1, 2, and 3 were 39%, 10%, and 0%, respectively (p < 0.05 for groups 1 vs 2; p > 0.05 for groups 1 vs 3 and groups 2 vs 3). CONCLUSION. The histologic grade of HCC is an important factor influencing therapeutic results with survival after radiofrequency ablation.

AB - OBJECTIVE. The purpose of our study was to assess the therapeutic results of radiofrequency ablation of hepatocellular carcinoma (HCC) based on the histologic grades of the tumors. SUBJECTS AMD METHODS. Between April 1999 and December 2003, 95 patients with nodular HCC were treated with percutaneous radiofrequency ablation. All tumors were histologically proven by sonography-guided percutaneous biopsy and were classified as Edmondson-Steiner grade IHCC (n = 38) (mean, 2.3 cm) (group 1), grade IIHCC (n = 50) (mean, 2.4 cm) (group 2), or grade III HCC (n = 7) (mean, 2.8 cm) (group 3). All patients underwent contrast-enhanced three-phase helical CT examination before and after radiofrequency ablation. After retrospective review of the medical records and follow-up CT examinations, the rates of technique effectiveness, local tumor progression, cumulative survival, and cancer-free survival using a Kaplan-Meier method were calculated and compared among the groups. RESULTS. Technique effectiveness rates in groups 1, 2, and 3 were 87% (27/31), 71% (30/42), and 43% (3/7), respectively, with statistical significance (p = 0.032). Local tumor progression rates in groups 1,2, and 3 were 16% (5/31), 36% (15/42), and 71% (5/7), respectively, with statistical significance (p = 0.013). Five-year cumulative survival rates in groups 1, 2, and 3 were 71%, 44%, and 43%, respectively, with no statistical significance (p > 0.05). Four-year cancer-free survival rates in groups 1, 2, and 3 were 39%, 10%, and 0%, respectively (p < 0.05 for groups 1 vs 2; p > 0.05 for groups 1 vs 3 and groups 2 vs 3). CONCLUSION. The histologic grade of HCC is an important factor influencing therapeutic results with survival after radiofrequency ablation.

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KW - Hepatocellular carcinoma

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