Abstract
Objective: To compare a newly developed minimally-invasive method for percutaneous transforaminalepidural injection (INJ group) with the existing method for lumbar epidural catheterization (CATH group).Method: Through anatomical review of experimental rats, the cephalic one fourth of the neural foramen was selected as the target point for drug delivery. After the rats had undergone lumbar epidural catheterization, lidocaine, and 1% methylene blue were injected through the unilateral or bilateral L5/6 neural foramen in the INJ group, and through an epidural catheter in the CATH group. Measurement of body weight and the mechanical allodynia test before and after injection of lidocaine, and fine dissection after injection were performed.Results: Results of the mechanical allodynia test of 1.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 0.5% lidocaine 100 μl injection in the INJ group. The results of 2.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 1.0% lidocaine 100 ml injection in the INJ group. After dissection, only one distal partial spinal nerve was stained by methylene blue 50 μl through the transforaminal pathway. However, the dorsal root ganglion, nerve root, and adjacent hemi-partial spinal cord were stained by methylene blue 100 ml through the transforaminal pathway.Conclusion: The percutaneous transforaminal epidural injection is practical, easy, and safe, and, in particular, does not cause significant pain compared to the existing lumbar epidural catheterization. We expect this method to be effective in an animal study showing that drug delivery to the spinal epidural space is necessary.
| Original language | English |
|---|---|
| Pages (from-to) | 640-647 |
| Number of pages | 8 |
| Journal | Annals of Rehabilitation Medicine |
| Volume | 36 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
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Keywords
- Animal study
- Epidural catheterization
- Lidocaine
- Pain
- Transforaminal
ASJC Scopus subject areas
- Rehabilitation
Cite this
Percutaneous transforaminal epidural injection method in an experimental rat : Minimally invasivedrug delivery method to spinal epidural space. / Kim, Nack Hwan; Lee, Sang Heon; Lee, Seok Jun.
In: Annals of Rehabilitation Medicine, Vol. 36, No. 5, 01.12.2012, p. 640-647.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Percutaneous transforaminal epidural injection method in an experimental rat
T2 - Minimally invasivedrug delivery method to spinal epidural space
AU - Kim, Nack Hwan
AU - Lee, Sang Heon
AU - Lee, Seok Jun
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Objective: To compare a newly developed minimally-invasive method for percutaneous transforaminalepidural injection (INJ group) with the existing method for lumbar epidural catheterization (CATH group).Method: Through anatomical review of experimental rats, the cephalic one fourth of the neural foramen was selected as the target point for drug delivery. After the rats had undergone lumbar epidural catheterization, lidocaine, and 1% methylene blue were injected through the unilateral or bilateral L5/6 neural foramen in the INJ group, and through an epidural catheter in the CATH group. Measurement of body weight and the mechanical allodynia test before and after injection of lidocaine, and fine dissection after injection were performed.Results: Results of the mechanical allodynia test of 1.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 0.5% lidocaine 100 μl injection in the INJ group. The results of 2.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 1.0% lidocaine 100 ml injection in the INJ group. After dissection, only one distal partial spinal nerve was stained by methylene blue 50 μl through the transforaminal pathway. However, the dorsal root ganglion, nerve root, and adjacent hemi-partial spinal cord were stained by methylene blue 100 ml through the transforaminal pathway.Conclusion: The percutaneous transforaminal epidural injection is practical, easy, and safe, and, in particular, does not cause significant pain compared to the existing lumbar epidural catheterization. We expect this method to be effective in an animal study showing that drug delivery to the spinal epidural space is necessary.
AB - Objective: To compare a newly developed minimally-invasive method for percutaneous transforaminalepidural injection (INJ group) with the existing method for lumbar epidural catheterization (CATH group).Method: Through anatomical review of experimental rats, the cephalic one fourth of the neural foramen was selected as the target point for drug delivery. After the rats had undergone lumbar epidural catheterization, lidocaine, and 1% methylene blue were injected through the unilateral or bilateral L5/6 neural foramen in the INJ group, and through an epidural catheter in the CATH group. Measurement of body weight and the mechanical allodynia test before and after injection of lidocaine, and fine dissection after injection were performed.Results: Results of the mechanical allodynia test of 1.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 0.5% lidocaine 100 μl injection in the INJ group. The results of 2.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 1.0% lidocaine 100 ml injection in the INJ group. After dissection, only one distal partial spinal nerve was stained by methylene blue 50 μl through the transforaminal pathway. However, the dorsal root ganglion, nerve root, and adjacent hemi-partial spinal cord were stained by methylene blue 100 ml through the transforaminal pathway.Conclusion: The percutaneous transforaminal epidural injection is practical, easy, and safe, and, in particular, does not cause significant pain compared to the existing lumbar epidural catheterization. We expect this method to be effective in an animal study showing that drug delivery to the spinal epidural space is necessary.
KW - Animal study
KW - Epidural catheterization
KW - Lidocaine
KW - Pain
KW - Transforaminal
UR - http://www.scopus.com/inward/record.url?scp=84872565436&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872565436&partnerID=8YFLogxK
U2 - 10.5535/arm.2012.36.5.640
DO - 10.5535/arm.2012.36.5.640
M3 - Article
C2 - 23185728
AN - SCOPUS:84872565436
VL - 36
SP - 640
EP - 647
JO - Annals of Rehabilitation Medicine
JF - Annals of Rehabilitation Medicine
SN - 2234-0645
IS - 5
ER -