Percutaneous transforaminal epidural injection method in an experimental rat

Minimally invasivedrug delivery method to spinal epidural space

Nack Hwan Kim, Sang Heon Lee, Seok Jun Lee

Research output: Contribution to journalArticle

Abstract

Objective: To compare a newly developed minimally-invasive method for percutaneous transforaminalepidural injection (INJ group) with the existing method for lumbar epidural catheterization (CATH group).Method: Through anatomical review of experimental rats, the cephalic one fourth of the neural foramen was selected as the target point for drug delivery. After the rats had undergone lumbar epidural catheterization, lidocaine, and 1% methylene blue were injected through the unilateral or bilateral L5/6 neural foramen in the INJ group, and through an epidural catheter in the CATH group. Measurement of body weight and the mechanical allodynia test before and after injection of lidocaine, and fine dissection after injection were performed.Results: Results of the mechanical allodynia test of 1.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 0.5% lidocaine 100 μl injection in the INJ group. The results of 2.0% lidocaine 50 μl injection in the CATH group were statistically similar to those of 1.0% lidocaine 100 ml injection in the INJ group. After dissection, only one distal partial spinal nerve was stained by methylene blue 50 μl through the transforaminal pathway. However, the dorsal root ganglion, nerve root, and adjacent hemi-partial spinal cord were stained by methylene blue 100 ml through the transforaminal pathway.Conclusion: The percutaneous transforaminal epidural injection is practical, easy, and safe, and, in particular, does not cause significant pain compared to the existing lumbar epidural catheterization. We expect this method to be effective in an animal study showing that drug delivery to the spinal epidural space is necessary.

Original languageEnglish
Pages (from-to)640-647
Number of pages8
JournalAnnals of Rehabilitation Medicine
Volume36
Issue number5
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Epidural Injections
Epidural Space
Lidocaine
Injections
Methylene Blue
Catheterization
Hyperalgesia
Dissection
Spinal Nerves
Spinal Ganglia
Pharmaceutical Preparations
Spinal Cord
Catheters
Head
Body Weight
Pain

Keywords

  • Animal study
  • Epidural catheterization
  • Lidocaine
  • Pain
  • Transforaminal

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Percutaneous transforaminal epidural injection method in an experimental rat : Minimally invasivedrug delivery method to spinal epidural space. / Kim, Nack Hwan; Lee, Sang Heon; Lee, Seok Jun.

In: Annals of Rehabilitation Medicine, Vol. 36, No. 5, 01.12.2012, p. 640-647.

Research output: Contribution to journalArticle

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abstract = "Objective: To compare a newly developed minimally-invasive method for percutaneous transforaminalepidural injection (INJ group) with the existing method for lumbar epidural catheterization (CATH group).Method: Through anatomical review of experimental rats, the cephalic one fourth of the neural foramen was selected as the target point for drug delivery. After the rats had undergone lumbar epidural catheterization, lidocaine, and 1{\%} methylene blue were injected through the unilateral or bilateral L5/6 neural foramen in the INJ group, and through an epidural catheter in the CATH group. Measurement of body weight and the mechanical allodynia test before and after injection of lidocaine, and fine dissection after injection were performed.Results: Results of the mechanical allodynia test of 1.0{\%} lidocaine 50 μl injection in the CATH group were statistically similar to those of 0.5{\%} lidocaine 100 μl injection in the INJ group. The results of 2.0{\%} lidocaine 50 μl injection in the CATH group were statistically similar to those of 1.0{\%} lidocaine 100 ml injection in the INJ group. After dissection, only one distal partial spinal nerve was stained by methylene blue 50 μl through the transforaminal pathway. However, the dorsal root ganglion, nerve root, and adjacent hemi-partial spinal cord were stained by methylene blue 100 ml through the transforaminal pathway.Conclusion: The percutaneous transforaminal epidural injection is practical, easy, and safe, and, in particular, does not cause significant pain compared to the existing lumbar epidural catheterization. We expect this method to be effective in an animal study showing that drug delivery to the spinal epidural space is necessary.",
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