Periodic leg movement, nasal CPAP, and expiratory muscles

Won Hee Seo, Christian Guilleminault

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Periodic leg movements (PLMs) may appear during nasal CPAP titration, persisting despite the elimination of hypopneas. Methods: Systematic recordings of expiratory abdominal muscles on the right and left sides with surface electromyographic (EMG) electrodes lateral to navel, and close from the lateral side of abdomen, were added during nasal CPAP titration for treatment of obstructive sleep apnea (OSA). Positive airway pressure was titrated during nocturnal polysomnography, based on analysis of the flow curve derived from the CPAP equipment and EEG analysis, including persistence of phases A2 and A3 of the cyclic alternating pattern (CAP). The requirement was to eliminate American Association of Sleep Medicine (AASM)-defined hypopnea and also flow limitation and abnormal EEG patterns. When CPAP reached valid results, it was lowered at the time of awakening by 2 or 3 cm H 2 O, and titration was performed again. Data collected during a 7-month period on adults with a prior diagnosis of OSA who had received treatment with nasal CPAP regardless of age and sex were rendered anonymous and were retrospectively rescored by a blinded investigator. Results: Eighty-one successively seen patients with PLMs during CPAP titration were investigated. Elimination of AASM-defined hypopnea was not sufficient to eliminate the PLMs observed during the titration; higher CPAP eliminated flow limitation and CAP phases A2 and A3 and persisting PLMs. PLMs were associated with simultaneous EMG bursts in expiratory abdominal muscles. Conclusions: The presence of PLMs during CPAP titration indicates the persistence of sleepdisordered breathing. PLMs during CPAP titration are related to the presence of abdominal expiratory muscle activity.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalChest
Volume142
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

Fingerprint

Nose
Leg
Muscles
Abdominal Muscles
Obstructive Sleep Apnea
varespladib methyl
Electroencephalography
Sleep
Medicine
Polysomnography
Abdomen
Electrodes
Respiration
Research Personnel
Pressure
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Periodic leg movement, nasal CPAP, and expiratory muscles. / Seo, Won Hee; Guilleminault, Christian.

In: Chest, Vol. 142, No. 1, 01.01.2012, p. 111-118.

Research output: Contribution to journalArticle

Seo, Won Hee ; Guilleminault, Christian. / Periodic leg movement, nasal CPAP, and expiratory muscles. In: Chest. 2012 ; Vol. 142, No. 1. pp. 111-118.
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