Abstract
Background The appropriate length of time for patients who visit clinics with significant suicidal ideation to be closely monitored is a critical issue for clinicians. We evaluated the course of suicidal ideation and associated factors for persistent suicidality in patients who entered treatment for depression with significant suicidal ideation. Methods A total of 565 patients who had both moderate to severe depression (Hamilton Depression Rating Scale (HAMD) score ≥14) and significant suicidal ideation (Beck Scale for Suicide Ideation (SSI-B) score ≥6) were recruited from 18 hospitals in South Korea. Participants were assessed using the SSI-B, HAMD, Hamilton Anxiety Rating Scale, and Clinical Global Impression Scale-severity during a 12-week naturalistic treatment with antidepressant intervention. Participants were classified into resolved suicidality or persistent suicidality groups according to whether their suicidal ideation improved to SSI-B scores <6 and were sustained for 12 weeks. Results During the 12-week treatment, 206 (36.4%) patients were classified in the resolved suicidality group. Persistent suicidality was associated with intervention with SSRIs, higher SSI-B baseline score, and no HAMD or HAMA remission. The proportions of participants who had persistent suicidal ideation even with HAMD remission or response were 0.25 and 0.34, respectively. Limitations This study was observational, and the treatment modality was naturalistic. Conclusions A considerable number of patients had persistent suicidal ideation despite 12 weeks of antidepressant treatment. Close monitoring for suicidal ideation may be needed beyond the initial weeks of treatment and even after a response to antidepressants is observed.
| Original language | English |
|---|---|
| Pages (from-to) | 208-215 |
| Number of pages | 8 |
| Journal | Journal of Affective Disorders |
| Volume | 155 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Feb 1 |
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Keywords
- Depression
- Persistent suicidality
- Predictive factor
- Resolved suicidality
- Suicide ideation
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Persistence and resolution of suicidal ideation during treatment of depression in patients with significant suicidality at the beginning of treatment : The CRESCEND study. / Seo, Ho Jun; Jung, Young Eun; Jeong, Seunghee; Kim, Jung Bum; Lee, Min-Soo; Kim, Jae Min; Yim, Hyeon Woo; Jun, Tae Youn.
In: Journal of Affective Disorders, Vol. 155, No. 1, 01.02.2014, p. 208-215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistence and resolution of suicidal ideation during treatment of depression in patients with significant suicidality at the beginning of treatment
T2 - The CRESCEND study
AU - Seo, Ho Jun
AU - Jung, Young Eun
AU - Jeong, Seunghee
AU - Kim, Jung Bum
AU - Lee, Min-Soo
AU - Kim, Jae Min
AU - Yim, Hyeon Woo
AU - Jun, Tae Youn
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Background The appropriate length of time for patients who visit clinics with significant suicidal ideation to be closely monitored is a critical issue for clinicians. We evaluated the course of suicidal ideation and associated factors for persistent suicidality in patients who entered treatment for depression with significant suicidal ideation. Methods A total of 565 patients who had both moderate to severe depression (Hamilton Depression Rating Scale (HAMD) score ≥14) and significant suicidal ideation (Beck Scale for Suicide Ideation (SSI-B) score ≥6) were recruited from 18 hospitals in South Korea. Participants were assessed using the SSI-B, HAMD, Hamilton Anxiety Rating Scale, and Clinical Global Impression Scale-severity during a 12-week naturalistic treatment with antidepressant intervention. Participants were classified into resolved suicidality or persistent suicidality groups according to whether their suicidal ideation improved to SSI-B scores <6 and were sustained for 12 weeks. Results During the 12-week treatment, 206 (36.4%) patients were classified in the resolved suicidality group. Persistent suicidality was associated with intervention with SSRIs, higher SSI-B baseline score, and no HAMD or HAMA remission. The proportions of participants who had persistent suicidal ideation even with HAMD remission or response were 0.25 and 0.34, respectively. Limitations This study was observational, and the treatment modality was naturalistic. Conclusions A considerable number of patients had persistent suicidal ideation despite 12 weeks of antidepressant treatment. Close monitoring for suicidal ideation may be needed beyond the initial weeks of treatment and even after a response to antidepressants is observed.
AB - Background The appropriate length of time for patients who visit clinics with significant suicidal ideation to be closely monitored is a critical issue for clinicians. We evaluated the course of suicidal ideation and associated factors for persistent suicidality in patients who entered treatment for depression with significant suicidal ideation. Methods A total of 565 patients who had both moderate to severe depression (Hamilton Depression Rating Scale (HAMD) score ≥14) and significant suicidal ideation (Beck Scale for Suicide Ideation (SSI-B) score ≥6) were recruited from 18 hospitals in South Korea. Participants were assessed using the SSI-B, HAMD, Hamilton Anxiety Rating Scale, and Clinical Global Impression Scale-severity during a 12-week naturalistic treatment with antidepressant intervention. Participants were classified into resolved suicidality or persistent suicidality groups according to whether their suicidal ideation improved to SSI-B scores <6 and were sustained for 12 weeks. Results During the 12-week treatment, 206 (36.4%) patients were classified in the resolved suicidality group. Persistent suicidality was associated with intervention with SSRIs, higher SSI-B baseline score, and no HAMD or HAMA remission. The proportions of participants who had persistent suicidal ideation even with HAMD remission or response were 0.25 and 0.34, respectively. Limitations This study was observational, and the treatment modality was naturalistic. Conclusions A considerable number of patients had persistent suicidal ideation despite 12 weeks of antidepressant treatment. Close monitoring for suicidal ideation may be needed beyond the initial weeks of treatment and even after a response to antidepressants is observed.
KW - Depression
KW - Persistent suicidality
KW - Predictive factor
KW - Resolved suicidality
KW - Suicide ideation
UR - http://www.scopus.com/inward/record.url?scp=84891842285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891842285&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2013.11.002
DO - 10.1016/j.jad.2013.11.002
M3 - Article
C2 - 24262641
AN - SCOPUS:84891842285
VL - 155
SP - 208
EP - 215
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1
ER -