Persistent anemia in a patient with diffuse large B cell lymphoma: Pure red cell aplasia associated with latent Epstein-Barr virus infection in bone marrow

Jung Sung Hwa, Jin Kim Seok, Ji Hye Lee, Goeun Lee, Kyung A. Lee, Won Choi Chul, Soo Kim Byung, Suk Kim Jun

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma. Persistent anemia without an obvious cause was observed in a 47-yr-old man diagnosed with relapsed diffuse large B cell lymphoma. The bone marrow study showed only erythroid hypoplasia without the evidence of bone marrow involvement with lymphoma cells, thus PRCA was suggested. However, parvovirus infection was excluded as a potential cause of PRCA because of negative IgM anti-parvovirus B19 antibody and negative parvovirus PCR in the serum. Latent Epstein-Barr virus (EBV) infection of bone marrow was suggested by in situ hybridization with EBV-encoded small RNA (EBER) that showed a strong positive expression in bone marrow cells. Thus, PRCA was thought to be associated with latent EBV infection in bone marrow cells. Although the finding of unexplained anemia is a possible predictor of bone marrow involvement with lymphoma cells, PRCA as a result of a viral infection including EBV should be considered in lymphoma patients. This is the first report of the occurrence of PRCA associated with latent EBV infection in a patient with non-Hodgkin's lymphoma.

Original languageEnglish
Pages (from-to)S167-S170
JournalJournal of Korean medical science
Volume22
Issue numberSUPPL.
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • Epstein-Barr virus
  • Lymphoma
  • Red-cell aplasia

ASJC Scopus subject areas

  • Medicine(all)

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