Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students

Byung-Joo Ham, Young-Mee Lee, Meyoung-Kon Kim, Juneyoung Lee, Duck-Sun Ahn, Myoung Jin Choi, Kyoon Lyoo In, Ihn Geun Choi, Min-Soo Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This study investigated the relationships between genetic polymorphisms, personality traits, and academic achievement in medical school students. Study subjects were 220 1st-year medical students at Korea University Medical School during two consecutive academic years (2003-2004). Grade-point averages (GPA) during the second semester of the 1st year of the medical school were obtained as a measure of academic achievement. In addition, all participants completed the Temperament and Character Inventory and questionnaires on depression and anxiety. The polymorphisms in exon III of the dopamine D4 receptor (DRD4) were determined using the polymerase chain reaction. Our results revealed that both male and female subjects with a higher GPA may be characterized as having higher persistence and lower novelty seeking traits. In addition, male subjects with high GPA had higher scores in self directedness and female subjects with a higher GPA may be characterized as having higher scores in harm avoidance. Male students with 4-repeat alleles had a significantly lower GPA than male students without 4-repeat alleles.This relationship also remained after controlling for the personality variables, none of which showed a relationship with the polymorphism after Bonferroni correction. For females, however, no associations could be found between GPA and the polymorphism. Thus, the present study demonstrated for the first time a possible influence of the DRD4 48 bp variable number of tandem repeats polymorphism on academic achievement and proved that this was not mediated by performance-associated personality traits.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalNeuropsychobiology
Volume53
Issue number4
DOIs
Publication statusPublished - 2006 Aug 1

Fingerprint

Dopamine D4 Receptors
Medical Students
Personality
Exons
Medical Schools
Alleles
Students
Minisatellite Repeats
Temperament
Ego
Genetic Polymorphisms
Korea
Anxiety
Depression
Equipment and Supplies
Polymerase Chain Reaction

Keywords

  • Academic achievement
  • Dopamine D4 receptor
  • Personality traits

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students. / Ham, Byung-Joo; Lee, Young-Mee; Kim, Meyoung-Kon; Lee, Juneyoung; Ahn, Duck-Sun; Choi, Myoung Jin; In, Kyoon Lyoo; Choi, Ihn Geun; Lee, Min-Soo.

In: Neuropsychobiology, Vol. 53, No. 4, 01.08.2006, p. 203-209.

Research output: Contribution to journalArticle

Ham, Byung-Joo ; Lee, Young-Mee ; Kim, Meyoung-Kon ; Lee, Juneyoung ; Ahn, Duck-Sun ; Choi, Myoung Jin ; In, Kyoon Lyoo ; Choi, Ihn Geun ; Lee, Min-Soo. / Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students. In: Neuropsychobiology. 2006 ; Vol. 53, No. 4. pp. 203-209.
@article{d521ecda4a9a458c8525cb86640184eb,
title = "Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students",
abstract = "This study investigated the relationships between genetic polymorphisms, personality traits, and academic achievement in medical school students. Study subjects were 220 1st-year medical students at Korea University Medical School during two consecutive academic years (2003-2004). Grade-point averages (GPA) during the second semester of the 1st year of the medical school were obtained as a measure of academic achievement. In addition, all participants completed the Temperament and Character Inventory and questionnaires on depression and anxiety. The polymorphisms in exon III of the dopamine D4 receptor (DRD4) were determined using the polymerase chain reaction. Our results revealed that both male and female subjects with a higher GPA may be characterized as having higher persistence and lower novelty seeking traits. In addition, male subjects with high GPA had higher scores in self directedness and female subjects with a higher GPA may be characterized as having higher scores in harm avoidance. Male students with 4-repeat alleles had a significantly lower GPA than male students without 4-repeat alleles.This relationship also remained after controlling for the personality variables, none of which showed a relationship with the polymorphism after Bonferroni correction. For females, however, no associations could be found between GPA and the polymorphism. Thus, the present study demonstrated for the first time a possible influence of the DRD4 48 bp variable number of tandem repeats polymorphism on academic achievement and proved that this was not mediated by performance-associated personality traits.",
keywords = "Academic achievement, Dopamine D4 receptor, Personality traits",
author = "Byung-Joo Ham and Young-Mee Lee and Meyoung-Kon Kim and Juneyoung Lee and Duck-Sun Ahn and Choi, {Myoung Jin} and In, {Kyoon Lyoo} and Choi, {Ihn Geun} and Min-Soo Lee",
year = "2006",
month = "8",
day = "1",
doi = "10.1159/000094729",
language = "English",
volume = "53",
pages = "203--209",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students

AU - Ham, Byung-Joo

AU - Lee, Young-Mee

AU - Kim, Meyoung-Kon

AU - Lee, Juneyoung

AU - Ahn, Duck-Sun

AU - Choi, Myoung Jin

AU - In, Kyoon Lyoo

AU - Choi, Ihn Geun

AU - Lee, Min-Soo

PY - 2006/8/1

Y1 - 2006/8/1

N2 - This study investigated the relationships between genetic polymorphisms, personality traits, and academic achievement in medical school students. Study subjects were 220 1st-year medical students at Korea University Medical School during two consecutive academic years (2003-2004). Grade-point averages (GPA) during the second semester of the 1st year of the medical school were obtained as a measure of academic achievement. In addition, all participants completed the Temperament and Character Inventory and questionnaires on depression and anxiety. The polymorphisms in exon III of the dopamine D4 receptor (DRD4) were determined using the polymerase chain reaction. Our results revealed that both male and female subjects with a higher GPA may be characterized as having higher persistence and lower novelty seeking traits. In addition, male subjects with high GPA had higher scores in self directedness and female subjects with a higher GPA may be characterized as having higher scores in harm avoidance. Male students with 4-repeat alleles had a significantly lower GPA than male students without 4-repeat alleles.This relationship also remained after controlling for the personality variables, none of which showed a relationship with the polymorphism after Bonferroni correction. For females, however, no associations could be found between GPA and the polymorphism. Thus, the present study demonstrated for the first time a possible influence of the DRD4 48 bp variable number of tandem repeats polymorphism on academic achievement and proved that this was not mediated by performance-associated personality traits.

AB - This study investigated the relationships between genetic polymorphisms, personality traits, and academic achievement in medical school students. Study subjects were 220 1st-year medical students at Korea University Medical School during two consecutive academic years (2003-2004). Grade-point averages (GPA) during the second semester of the 1st year of the medical school were obtained as a measure of academic achievement. In addition, all participants completed the Temperament and Character Inventory and questionnaires on depression and anxiety. The polymorphisms in exon III of the dopamine D4 receptor (DRD4) were determined using the polymerase chain reaction. Our results revealed that both male and female subjects with a higher GPA may be characterized as having higher persistence and lower novelty seeking traits. In addition, male subjects with high GPA had higher scores in self directedness and female subjects with a higher GPA may be characterized as having higher scores in harm avoidance. Male students with 4-repeat alleles had a significantly lower GPA than male students without 4-repeat alleles.This relationship also remained after controlling for the personality variables, none of which showed a relationship with the polymorphism after Bonferroni correction. For females, however, no associations could be found between GPA and the polymorphism. Thus, the present study demonstrated for the first time a possible influence of the DRD4 48 bp variable number of tandem repeats polymorphism on academic achievement and proved that this was not mediated by performance-associated personality traits.

KW - Academic achievement

KW - Dopamine D4 receptor

KW - Personality traits

UR - http://www.scopus.com/inward/record.url?scp=33747423331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747423331&partnerID=8YFLogxK

U2 - 10.1159/000094729

DO - 10.1159/000094729

M3 - Article

VL - 53

SP - 203

EP - 209

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 4

ER -