Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication

Jeong Yoon Choi, Young Min Park, Yeon Sun Woo, Sung Un Kim, Jin-Man Jung, Do-Young Kwon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.

Original languageEnglish
Pages (from-to)243-244
Number of pages2
JournalJournal of the Neurological Sciences
Volume337
Issue number1-2
DOIs
Publication statusPublished - 2014 Feb 15

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Physiologic Nystagmus
Head
Cerebellar Diseases
Dizziness
Ataxia
Brain Stem
Prescriptions
Neurotransmitter Agents
Central Nervous System
Pregabalin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication. / Choi, Jeong Yoon; Park, Young Min; Woo, Yeon Sun; Kim, Sung Un; Jung, Jin-Man; Kwon, Do-Young.

In: Journal of the Neurological Sciences, Vol. 337, No. 1-2, 15.02.2014, p. 243-244.

Research output: Contribution to journalArticle

Choi, Jeong Yoon ; Park, Young Min ; Woo, Yeon Sun ; Kim, Sung Un ; Jung, Jin-Man ; Kwon, Do-Young. / Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication. In: Journal of the Neurological Sciences. 2014 ; Vol. 337, No. 1-2. pp. 243-244.
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