Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication

Jeong Yoon Choi, Young Min Park, Yeon Sun Woo, Sung Un Kim, Jin-Man Jung, Do-Young Kwon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.

Original languageEnglish
Pages (from-to)243-244
Number of pages2
JournalJournal of the Neurological Sciences
Volume337
Issue number1-2
DOIs
Publication statusPublished - 2014 Feb 15

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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