pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Woo Sun Shim, Jong Ho Kim, Kwangmeyung Kim, Yoo Shin Kim, Rang Woon Park, In San Kim, Ick Chan Kwon, Doo Sung Lee

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume331
Issue number1
DOIs
Publication statusPublished - 2007 Feb 22

Keywords

  • In vivo anti-tumor effect
  • Injectable hydrogel
  • Paclitaxel
  • TUNEL assay
  • pH/T-sensitive block copolymer hydrogel

ASJC Scopus subject areas

  • Pharmaceutical Science

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