pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Woo Sun Shim, Jong Ho Kim, Kwang Meyung Kim, Yoo Shin Kim, Rang Woon Park, In-San Kim, Ick Chan Kwon, Doo Sung Lee

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume331
Issue number1
DOIs
Publication statusPublished - 2007 Feb 22
Externally publishedYes

Fingerprint

Hydrogels
Paclitaxel
Injections
Temperature
Neoplasms
Hydrogel
In Situ Nick-End Labeling
Apoptosis

Keywords

  • In vivo anti-tumor effect
  • Injectable hydrogel
  • Paclitaxel
  • pH/T-sensitive block copolymer hydrogel
  • TUNEL assay

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel. / Shim, Woo Sun; Kim, Jong Ho; Kim, Kwang Meyung; Kim, Yoo Shin; Park, Rang Woon; Kim, In-San; Kwon, Ick Chan; Lee, Doo Sung.

In: International Journal of Pharmaceutics, Vol. 331, No. 1, 22.02.2007, p. 11-18.

Research output: Contribution to journalArticle

Shim, Woo Sun ; Kim, Jong Ho ; Kim, Kwang Meyung ; Kim, Yoo Shin ; Park, Rang Woon ; Kim, In-San ; Kwon, Ick Chan ; Lee, Doo Sung. / pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel. In: International Journal of Pharmaceutics. 2007 ; Vol. 331, No. 1. pp. 11-18.
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AU - Park, Rang Woon

AU - Kim, In-San

AU - Kwon, Ick Chan

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