PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Jin Young Ko, Sangjin Park, Hyejung Lee, Heebeom Koo, Min Sang Kim, Kuiwon Choi, Ick Chan Kwon, Seo Young Jeong, Kwang Meyung Kim, Doo Sung Lee

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

Original languageEnglish
Pages (from-to)2539-2544
Number of pages6
JournalSmall
Volume6
Issue number22
DOIs
Publication statusPublished - 2010 Nov 22
Externally publishedYes

Fingerprint

Micelles
Animals
Imaging techniques
Fluorescent Dyes
Chain length
Block copolymers
Amplification
Esters
Dyes
Fluorescence
In Vitro Techniques

Keywords

  • block copolymers
  • fluorescent probes
  • micelles
  • nanoparticles
  • tumor imaging

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Ko, J. Y., Park, S., Lee, H., Koo, H., Kim, M. S., Choi, K., ... Lee, D. S. (2010). PH-sensitive nanoflash for tumoral acidic pH imaging in live animals. Small, 6(22), 2539-2544. https://doi.org/10.1002/smll.201001252

PH-sensitive nanoflash for tumoral acidic pH imaging in live animals. / Ko, Jin Young; Park, Sangjin; Lee, Hyejung; Koo, Heebeom; Kim, Min Sang; Choi, Kuiwon; Kwon, Ick Chan; Jeong, Seo Young; Kim, Kwang Meyung; Lee, Doo Sung.

In: Small, Vol. 6, No. 22, 22.11.2010, p. 2539-2544.

Research output: Contribution to journalArticle

Ko, JY, Park, S, Lee, H, Koo, H, Kim, MS, Choi, K, Kwon, IC, Jeong, SY, Kim, KM & Lee, DS 2010, 'PH-sensitive nanoflash for tumoral acidic pH imaging in live animals', Small, vol. 6, no. 22, pp. 2539-2544. https://doi.org/10.1002/smll.201001252
Ko JY, Park S, Lee H, Koo H, Kim MS, Choi K et al. PH-sensitive nanoflash for tumoral acidic pH imaging in live animals. Small. 2010 Nov 22;6(22):2539-2544. https://doi.org/10.1002/smll.201001252
Ko, Jin Young ; Park, Sangjin ; Lee, Hyejung ; Koo, Heebeom ; Kim, Min Sang ; Choi, Kuiwon ; Kwon, Ick Chan ; Jeong, Seo Young ; Kim, Kwang Meyung ; Lee, Doo Sung. / PH-sensitive nanoflash for tumoral acidic pH imaging in live animals. In: Small. 2010 ; Vol. 6, No. 22. pp. 2539-2544.
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