PH-sensitive nanoflash for tumoral acidic pH imaging in live animals

Jin Young Ko, Sangjin Park, Hyejung Lee, Heebeom Koo, Min Sang Kim, Kuiwon Choi, Ick Chan Kwon, Seo Young Jeong, Kwangmeyung Kim, Doo Sung Lee

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Block-copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.

Original languageEnglish
Pages (from-to)2539-2544
Number of pages6
JournalSmall
Volume6
Issue number22
DOIs
Publication statusPublished - 2010 Nov 22

Keywords

  • block copolymers
  • fluorescent probes
  • micelles
  • nanoparticles
  • tumor imaging

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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  • Cite this

    Ko, J. Y., Park, S., Lee, H., Koo, H., Kim, M. S., Choi, K., Kwon, I. C., Jeong, S. Y., Kim, K., & Lee, D. S. (2010). PH-sensitive nanoflash for tumoral acidic pH imaging in live animals. Small, 6(22), 2539-2544. https://doi.org/10.1002/smll.201001252