pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging

Yi Li, Guang Hui Gao, Ick Chan Kwon, Doo Sung Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Safe and efficient diagnosis and therapy of cancers are important and of great interest these years. Multifunctional polymeric nanoparticles incorporating therapeutic and imaging agents are powerful tools for simultaneous therapy and diagnosis (theranostics). The most frequently used biodegradable polymers in drug-delivery systems (DDSs) are polycaprolactone (PCL), poly(glycolic acid) (PGA), poly(lactic acid) (PLA), and their copolymers. This chapter discusses different types of pH-sensitive polymers and the DDSs based on them. The synthesis of pH-sensitive polymers and the fabrication and assessment (in vivo and in vitro) of pH-sensitive DDSs are addressed. Polymers with fine and controllable structures are very important for biomedical applications. The availability of numerous techniques for synthesizing polymers affords the ability to prepare polymers with diverse fine structures, allowing DDSs to be fabricated for different purpose by choosing the appropriate polymers.

Original languageEnglish
Title of host publicationBioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery
PublisherWiley Blackwell
Pages203-222
Number of pages20
ISBN (Print)9783527672752, 9783527334209
DOIs
Publication statusPublished - 2015 Mar 9
Externally publishedYes

Keywords

  • Biodegradable polymers
  • Biomedical applications
  • Cancer therapy
  • Imaging agents
  • PH-sensitive drug-delivery systems (DDSs)
  • PH-sensitive polymers
  • Polymeric nanoparticles

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Li, Y., Gao, G. H., Kwon, I. C., & Lee, D. S. (2015). pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging. In Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery (pp. 203-222). Wiley Blackwell. https://doi.org/10.1002/9783527672752.ch8