Abstract
pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
| Original language | English |
|---|---|
| Pages (from-to) | 2436-2442 |
| Number of pages | 7 |
| Journal | Advanced Materials |
| Volume | 23 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2011 Jun 3 |
Keywords
- drug delivery
- magnetic resonance imaging
- nanoparticles
- theragnostics
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
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Cite this
Lim, E. K., Huh, Y. M., Yang, J., Lee, K., Suh, J. S., & Haam, S. (2011). PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI. Advanced Materials, 23(21), 2436-2442. https://doi.org/10.1002/adma.201100351