PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI

Eun Kyung Lim; Yong Min Huh; Jaemoon Yang; Kwangyeol Lee; Jin Suck Suh; Seungjoo Haam

doi:10.1002/adma.201100351

PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI

Eun Kyung Lim, Yong Min Huh, Jaemoon Yang, Kwangyeol Lee, Jin Suck Suh, Seungjoo Haam

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

173 Citations (Scopus)

Abstract

pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.

Original language	English
Pages (from-to)	2436-2442
Number of pages	7
Journal	Advanced Materials
Volume	23
Issue number	21
DOIs	https://doi.org/10.1002/adma.201100351
Publication status	Published - 2011 Jun 3

Keywords

drug delivery
magnetic resonance imaging
nanoparticles
theragnostics

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1002/adma.201100351

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abstract = "pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.",

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AU - Suh, Jin Suck

AU - Haam, Seungjoo

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AB - pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.

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KW - magnetic resonance imaging

KW - nanoparticles

KW - theragnostics

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PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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