Abstract
pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
| Original language | English |
|---|---|
| Pages (from-to) | 2436-2442 |
| Number of pages | 7 |
| Journal | Advanced Materials |
| Volume | 23 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2011 Jun 3 |
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Keywords
- drug delivery
- magnetic resonance imaging
- nanoparticles
- theragnostics
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI. / Lim, Eun Kyung; Huh, Yong Min; Yang, Jaemoon; Lee, Kwangyeol; Suh, Jin Suck; Haam, Seungjoo.
In: Advanced Materials, Vol. 23, No. 21, 03.06.2011, p. 2436-2442.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI
AU - Lim, Eun Kyung
AU - Huh, Yong Min
AU - Yang, Jaemoon
AU - Lee, Kwangyeol
AU - Suh, Jin Suck
AU - Haam, Seungjoo
PY - 2011/6/3
Y1 - 2011/6/3
N2 - pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
AB - pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
KW - drug delivery
KW - magnetic resonance imaging
KW - nanoparticles
KW - theragnostics
UR - http://www.scopus.com/inward/record.url?scp=79957815663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957815663&partnerID=8YFLogxK
U2 - 10.1002/adma.201100351
DO - 10.1002/adma.201100351
M3 - Article
VL - 23
SP - 2436
EP - 2442
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 21
ER -