PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI

Eun Kyung Lim, Yong Min Huh, Jaemoon Yang, Kwangyeol Lee, Jin Suck Suh, Seungjoo Haam

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.

Original languageEnglish
Pages (from-to)2436-2442
Number of pages7
JournalAdvanced Materials
Volume23
Issue number21
DOIs
Publication statusPublished - 2011 Jun 3

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Molecular imaging
Magnetic resonance
Nanoparticles
Imaging techniques
Cells
Pharmaceutical Preparations
Doxorubicin
Tumors
Kinetics

Keywords

  • drug delivery
  • magnetic resonance imaging
  • nanoparticles
  • theragnostics

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI. / Lim, Eun Kyung; Huh, Yong Min; Yang, Jaemoon; Lee, Kwangyeol; Suh, Jin Suck; Haam, Seungjoo.

In: Advanced Materials, Vol. 23, No. 21, 03.06.2011, p. 2436-2442.

Research output: Contribution to journalArticle

Lim, Eun Kyung ; Huh, Yong Min ; Yang, Jaemoon ; Lee, Kwangyeol ; Suh, Jin Suck ; Haam, Seungjoo. / PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI. In: Advanced Materials. 2011 ; Vol. 23, No. 21. pp. 2436-2442.
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