PH-triggered drug-releasing magnetic nanoparticles for cancer therapy guided by molecular imaging by MRI

Eun Kyung Lim, Yong Min Huh, Jaemoon Yang, Kwangyeol Lee, Jin Suck Suh, Seungjoo Haam

Research output: Contribution to journalArticlepeer-review

167 Citations (Scopus)

Abstract

pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.

Original languageEnglish
Pages (from-to)2436-2442
Number of pages7
JournalAdvanced Materials
Volume23
Issue number21
DOIs
Publication statusPublished - 2011 Jun 3

Keywords

  • drug delivery
  • magnetic resonance imaging
  • nanoparticles
  • theragnostics

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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