Pharmacogenetics of aspirin-intolerant asthma

Seung Hyun Kim, Gyu Young Hur, Jeong Hee Choi, Hae Sim Park

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Leukotriene overproduction is the major characteristic of aspirin-intolerant asthma (AIA). Most studies examining the molecular genetic mechanisms of AIA have focused on leukotriene-related genes, including ALOX5, LTC4S, TXA2R and prostanoid-receptor genes. One study suggested that the human leukocyte antigen (HLA) allele DPB1*0301 may be a genetic marker for the AIA phenotype in European and Asian populations, and HLA-DPB1*0301 has been suggested as a useful genetic marker for predicting more favorable responders to leukotriene-receptor antagonists for long-term management of AIA. Although several reports have indicated possible associations between genetic polymorphisms and variable responses to leukotriene modifiers in nonaspirin sensitive asthmatic patients, few have suggested relationships between such genetic polymorphisms and variable responses to asthma drugs in AIA patients.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalPharmacogenomics
Volume9
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1
Externally publishedYes

Fingerprint

Pharmacogenetics
Aspirin
Asthma
Leukotrienes
Genetic Polymorphisms
HLA Antigens
Genetic Markers
Leukotriene Antagonists
Genes
Prostaglandins
Molecular Biology
Alleles
Phenotype
Pharmaceutical Preparations
Population

Keywords

  • Aspirin-intolerant asthma
  • Cysteinyl leukotriene receptor type 1
  • Leukotriene
  • Pharmacogenetic

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

Cite this

Pharmacogenetics of aspirin-intolerant asthma. / Kim, Seung Hyun; Hur, Gyu Young; Choi, Jeong Hee; Park, Hae Sim.

In: Pharmacogenomics, Vol. 9, No. 1, 01.01.2008, p. 85-91.

Research output: Contribution to journalReview article

Kim, Seung Hyun ; Hur, Gyu Young ; Choi, Jeong Hee ; Park, Hae Sim. / Pharmacogenetics of aspirin-intolerant asthma. In: Pharmacogenomics. 2008 ; Vol. 9, No. 1. pp. 85-91.
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