Pharmacogenetics of aspirin-intolerant asthma

Seung Hyun Kim, Gyu Young Hur, Jeong Hee Choi, Hae Sim Park

    Research output: Contribution to journalReview articlepeer-review

    30 Citations (Scopus)

    Abstract

    Leukotriene overproduction is the major characteristic of aspirin-intolerant asthma (AIA). Most studies examining the molecular genetic mechanisms of AIA have focused on leukotriene-related genes, including ALOX5, LTC4S, TXA2R and prostanoid-receptor genes. One study suggested that the human leukocyte antigen (HLA) allele DPB1*0301 may be a genetic marker for the AIA phenotype in European and Asian populations, and HLA-DPB1*0301 has been suggested as a useful genetic marker for predicting more favorable responders to leukotriene-receptor antagonists for long-term management of AIA. Although several reports have indicated possible associations between genetic polymorphisms and variable responses to leukotriene modifiers in nonaspirin sensitive asthmatic patients, few have suggested relationships between such genetic polymorphisms and variable responses to asthma drugs in AIA patients.

    Original languageEnglish
    Pages (from-to)85-91
    Number of pages7
    JournalPharmacogenomics
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - 2008 Jan

    Keywords

    • Aspirin-intolerant asthma
    • Cysteinyl leukotriene receptor type 1
    • Leukotriene
    • Pharmacogenetic

    ASJC Scopus subject areas

    • Molecular Medicine
    • Genetics
    • Pharmacology

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