Pharmacologic treatment of acute kidney injury: Why drugs haven't worked and what is on the horizon

Sang Kyung Jo, Mitchell H. Rosner, Mark D. Okusa

Research output: Contribution to journalShort survey

173 Citations (Scopus)


Current strategies to limit the extent of injury in acute renal failure are based on extensive studies that identified cellular and molecular mechanisms of acute kidney injury. Despite successes in various animal models, translation to human studies has failed or studies are inconclusive. This review describes past failures and barriers to successful clinical trials. It also focuses on promising preclinical studies using novel compounds that currently are in or close to human investigation. Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder.

Original languageEnglish
Pages (from-to)356-365
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Issue number2
Publication statusPublished - 2007 Mar 1
Externally publishedYes


ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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