Pharmacological activities of stromata of Cordyceps scarabaecola

K. W. Yu, K. M. Kim, Hyung Joo Suh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2 - generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalPhytotherapy Research
Volume17
Issue number3
DOIs
Publication statusPublished - 2003 Mar 1

Fingerprint

Cordyceps
Ashes
Carbohydrates
Pharmacology
Acidic Amino Acids
Water
Immune system
Mannose
Galactose
Aspartic Acid
Anticoagulants
Glutamic Acid
Immune System
Fats
Modulation
Glucose
Chemical analysis
Proteins

Keywords

  • Anticoagulant
  • Anticomplementary
  • Cordyceps scarabaecola
  • Inhibition of radical generation
  • Intestinal immune system modulation
  • Stromata

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pharmacological activities of stromata of Cordyceps scarabaecola. / Yu, K. W.; Kim, K. M.; Suh, Hyung Joo.

In: Phytotherapy Research, Vol. 17, No. 3, 01.03.2003, p. 244-249.

Research output: Contribution to journalArticle

Yu, K. W. ; Kim, K. M. ; Suh, Hyung Joo. / Pharmacological activities of stromata of Cordyceps scarabaecola. In: Phytotherapy Research. 2003 ; Vol. 17, No. 3. pp. 244-249.
@article{34edc412b13e4f73893d208d591929d1,
title = "Pharmacological activities of stromata of Cordyceps scarabaecola",
abstract = "The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1{\%}) and crude proteins (14.2{\%}). The stromata were also composed of a low content of crude ash (6.6{\%}) and fat (1.5{\%}). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6{\%}), mannose (35.4{\%}) and galactose (18.0{\%}). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62{\%} of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2 - generation as effectively as the positive control, genistine 27{\%}. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.",
keywords = "Anticoagulant, Anticomplementary, Cordyceps scarabaecola, Inhibition of radical generation, Intestinal immune system modulation, Stromata",
author = "Yu, {K. W.} and Kim, {K. M.} and Suh, {Hyung Joo}",
year = "2003",
month = "3",
day = "1",
doi = "10.1002/ptr.1119",
language = "English",
volume = "17",
pages = "244--249",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Pharmacological activities of stromata of Cordyceps scarabaecola

AU - Yu, K. W.

AU - Kim, K. M.

AU - Suh, Hyung Joo

PY - 2003/3/1

Y1 - 2003/3/1

N2 - The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2 - generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.

AB - The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2 - generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.

KW - Anticoagulant

KW - Anticomplementary

KW - Cordyceps scarabaecola

KW - Inhibition of radical generation

KW - Intestinal immune system modulation

KW - Stromata

UR - http://www.scopus.com/inward/record.url?scp=0037356236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037356236&partnerID=8YFLogxK

U2 - 10.1002/ptr.1119

DO - 10.1002/ptr.1119

M3 - Article

C2 - 12672154

AN - SCOPUS:0037356236

VL - 17

SP - 244

EP - 249

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 3

ER -