Pharmacological activities of stromata of Cordyceps scarabaecola

K. W. Yu, K. M. Kim, H. J. Suh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The chemical components of freeze-dried stromata from Cordyceps scarabaecola were examined. The stromata consisted of crude carbohydrates (55.1%) and crude proteins (14.2%). The stromata were also composed of a low content of crude ash (6.6%) and fat (1.5%). The composition of the carbohydrate in the stromata included a large quantity of glucose (46.6%), mannose (35.4%) and galactose (18.0%). The acidic amino acids such as glutamic acid (32.1 mg/g) and aspartic acid (24.7 mg/g) were present in a large quantity. The extracts of stromata did not reveal any inhibitory activity for AChE in vitro. It was observed that a hot-water extract (HW) of the stromata contributed significantly to the anticoagulant activity (60 s coagulating time) and anticomplementary activity (62% of ITCH50 value). The MeOH-soluble fraction (M) from the freeze-dried stromata inhibited TPA-induced O2- generation as effectively as the positive control, genistine 27%. The hot-water extract (HW) showed the most potent intestinal immune system modulation activity and the MeOH-soluble fraction (M) had intermediate activity.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalPhytotherapy Research
Volume17
Issue number3
DOIs
Publication statusPublished - 2003 Mar

Keywords

  • Anticoagulant
  • Anticomplementary
  • Cordyceps scarabaecola
  • Inhibition of radical generation
  • Intestinal immune system modulation
  • Stromata

ASJC Scopus subject areas

  • Pharmacology

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