Pharmacophore modeling of angiotensin-II from study of its nonpeptidic antagonists

Won Seok Oh, Hang Cheol Shin, Nakcheol Jeong, Jae M. Shin

Research output: Contribution to journalArticle

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Abstract

Early attempts to identify plausible conformations of a linear octapeptide hormone, angiotensin-II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe), using various theoretical and experimental methods, have led to various conformational models. So far, no consensus has been made about the solution phase structure and the receptor binding structure of angiotensin-II. The ultimate goal for the conformation study of the peptide hormone is to develop a new potent drug. Therefore, we have devised a strategy for designing the pharmacophore by studying thermodynamically possible conformations of various kinds of angiotensin-II antagonists and angiotensin-II.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalBulletin of the Korean Chemical Society
Volume17
Issue number2
Publication statusPublished - 1996 Dec 1
Externally publishedYes

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Angiotensin II
Conformations
Peptide Hormones
Phase structure
Hormones
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Pharmacophore modeling of angiotensin-II from study of its nonpeptidic antagonists. / Oh, Won Seok; Shin, Hang Cheol; Jeong, Nakcheol; Shin, Jae M.

In: Bulletin of the Korean Chemical Society, Vol. 17, No. 2, 01.12.1996, p. 182-188.

Research output: Contribution to journalArticle

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