Phase-contrast hard X-ray microscopy using synchrotron radiation for the diagnosis of onychomycosis

Onseok Lee, Seunghan Ha, Gunwoo Lee, Jaeyoung Kim, Jungyun Huang, Kyeongsik Jin, Chil Hwan Oh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Onychomycosis, or fungal infection of the nail, is a disease seen frequently in clinical settings. However, the rates of positive identification using potassium hydroxide preparations or fungal cultures are relatively low. Precise diagnosis is possible via histopathologic examination to monitor the existence of fungus and performance of a fungal culture for confirmation. Phase-contrast hard X-ray microscopy using synchrotron radiation provides 70-nm spatial resolution and enables imaging of minute internal cellular structures. This study confirms the feasibility of diagnosing onychomycosis using a phase-contrast hard X-ray microscope developed at 1B2 beam line using a Pohang light source. Microsc. Res. Tech. 73:1110-1114, 2010.

Original languageEnglish
Pages (from-to)1110-1114
Number of pages5
JournalMicroscopy Research and Technique
Volume73
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

X ray microscopes
Onychomycosis
Potassium hydroxide
Nails
Synchrotrons
phase contrast
Synchrotron radiation
Fungi
Light sources
Microscopy
Microscopic examination
synchrotron radiation
X-Rays
Radiation
microscopy
Imaging techniques
potassium hydroxides
X rays
fungi
Mycoses

Keywords

  • Onychomycosis
  • Phase-contrast X-ray
  • Synchrotron

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

Cite this

Phase-contrast hard X-ray microscopy using synchrotron radiation for the diagnosis of onychomycosis. / Lee, Onseok; Ha, Seunghan; Lee, Gunwoo; Kim, Jaeyoung; Huang, Jungyun; Jin, Kyeongsik; Oh, Chil Hwan.

In: Microscopy Research and Technique, Vol. 73, No. 12, 01.12.2010, p. 1110-1114.

Research output: Contribution to journalArticle

Lee, Onseok ; Ha, Seunghan ; Lee, Gunwoo ; Kim, Jaeyoung ; Huang, Jungyun ; Jin, Kyeongsik ; Oh, Chil Hwan. / Phase-contrast hard X-ray microscopy using synchrotron radiation for the diagnosis of onychomycosis. In: Microscopy Research and Technique. 2010 ; Vol. 73, No. 12. pp. 1110-1114.
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