Phase sensitive detection of vibrational Optical activity free-induction-decay: vibrational CD and ORD

Hanju Rhee, Young Gun June, Zee Hwan Kim, Seung-Joon Jeon, Minhaeng Cho

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Optical activity is manifested by chiral molecules including natural products and drugs, so that circular dichroism (CD) and optical rotatory dispersion (ORD) measurements can provide invaluable information on their chiro-optical properties and structures. It is experimentally demonstrated that heterodyne-detected Fouriertransform spectral interferometry with a femtosecond infrared pulse can be used to fully characterize the phase and amplitude of vibrational optical activity free-induction-decay field. The measured spectral interferograms are then converted to the linear optical activity susceptibility whose imaginary and real parts correspond to vibrational CD and ORD spectra. Unlike the conventional differential measurement technique, the present method based on a heterodyned interferometry is shown to be quite robust and stable. We anticipate that the present vibrational optical activity measurement technique will be of critical use in elucidating chirooptical properties and structural changes in biomolecules.

Original languageEnglish
Pages (from-to)1008-1017
Number of pages10
JournalJournal of the Optical Society of America B: Optical Physics
Volume26
Issue number5
DOIs
Publication statusPublished - 2009 May 1

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optical activity
dichroism
induction
interferometry
decay
drugs
magnetic permeability
optical properties
products
pulses
molecules

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Statistical and Nonlinear Physics

Cite this

Phase sensitive detection of vibrational Optical activity free-induction-decay : vibrational CD and ORD. / Rhee, Hanju; June, Young Gun; Kim, Zee Hwan; Jeon, Seung-Joon; Cho, Minhaeng.

In: Journal of the Optical Society of America B: Optical Physics, Vol. 26, No. 5, 01.05.2009, p. 1008-1017.

Research output: Contribution to journalArticle

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