Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

Ji Sang Hwang, Seon A. Lee, Seong Su Hong, Xiang Hua Han, Chul Lee, Shin Jung Kang, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

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30 Citations (Scopus)

Abstract

Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC50 values ranging from 9.6 μM to 35.7 μM.

Original languageEnglish
Pages (from-to)3785-3787
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number12
DOIs
Publication statusPublished - 2010 May 18

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Keywords

  • Bibenzyl
  • Dendrobium nobile
  • Nitric oxide inhibitor
  • Orchidaceae
  • Phenanthrene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Hwang, J. S., Lee, S. A., Hong, S. S., Han, X. H., Lee, C., Kang, S. J., Lee, D., Kim, Y., Hong, J. T., Lee, M. K., & Hwang, B. Y. (2010). Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells. Bioorganic and Medicinal Chemistry Letters, 20(12), 3785-3787. https://doi.org/10.1016/j.bmcl.2010.04.054