Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity

Yun Hyeok Choi, Seong Su Hong, Yu Su Shin, Bang Yeon Hwang, So Young Park, Dongho Lee

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED50 values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalArchives of pharmacal research
Volume33
Issue number10
DOIs
Publication statusPublished - 2010 Oct

Keywords

  • 2-(α,α-dimethylallyl)coumestrol
  • Beta-amyloid
  • Fabaceae
  • Isoflavone
  • Pueraria lobata

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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