Phenotypes and endotypes of severe asthma in children

Young Yoo

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identification of the phenotype clusters and endotypes of severe asthma can allow further modulation of the natural history of severe asthma and may provide the pathophysiologic rationale for appropriate management strategies.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalKorean Journal of Pediatrics
Volume56
Issue number5
DOIs
Publication statusPublished - 2013 May

Keywords

  • Child
  • Endotype
  • Phenotype
  • Severe asthma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

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