Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation

Mi Ran Byun, A. Rum Kim, Jun Ha Hwang, Mi Kyung Sung, Yeon Kyung Lee, Buyng Su Hwang, Jung Rae Rho, Eun Sook Hwang, Jeong Ho Hong

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK. Structured summary of protein interactions: TAZ physically interacts with RUNX2 by pull down (View interaction).

Original languageEnglish
Pages (from-to)1086-1092
Number of pages7
JournalFEBS Letters
Volume586
Issue number8
DOIs
Publication statusPublished - 2012 Apr 24

Keywords

  • Differentiation
  • ERK
  • Osteoblast
  • Phorbaketal A
  • TAZ

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Byun, M. R., Kim, A. R., Hwang, J. H., Sung, M. K., Lee, Y. K., Hwang, B. S., Rho, J. R., Hwang, E. S., & Hong, J. H. (2012). Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation. FEBS Letters, 586(8), 1086-1092. https://doi.org/10.1016/j.febslet.2012.03.008