Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation

Mi Ran Byun, A. Rum Kim, Jun Ha Hwang, Mi Kyung Sung, Yeon Kyung Lee, Buyng Su Hwang, Jung Rae Rho, Eun Sook Hwang, Jeong-Ho Hong

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK. Structured summary of protein interactions: TAZ physically interacts with RUNX2 by pull down (View interaction).

Original languageEnglish
Pages (from-to)1086-1092
Number of pages7
JournalFEBS Letters
Volume586
Issue number8
DOIs
Publication statusPublished - 2012 Apr 24

Fingerprint

Osteoblasts
Chemical activation
Bone
Bone Resorption
Biological Products
Osteogenesis
Osteoporosis
Genes
Molecules
phorbaketal A
Proteins

Keywords

  • Differentiation
  • ERK
  • Osteoblast
  • Phorbaketal A
  • TAZ

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Byun, M. R., Kim, A. R., Hwang, J. H., Sung, M. K., Lee, Y. K., Hwang, B. S., ... Hong, J-H. (2012). Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation. FEBS Letters, 586(8), 1086-1092. https://doi.org/10.1016/j.febslet.2012.03.008

Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation. / Byun, Mi Ran; Kim, A. Rum; Hwang, Jun Ha; Sung, Mi Kyung; Lee, Yeon Kyung; Hwang, Buyng Su; Rho, Jung Rae; Hwang, Eun Sook; Hong, Jeong-Ho.

In: FEBS Letters, Vol. 586, No. 8, 24.04.2012, p. 1086-1092.

Research output: Contribution to journalArticle

Byun, MR, Kim, AR, Hwang, JH, Sung, MK, Lee, YK, Hwang, BS, Rho, JR, Hwang, ES & Hong, J-H 2012, 'Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation', FEBS Letters, vol. 586, no. 8, pp. 1086-1092. https://doi.org/10.1016/j.febslet.2012.03.008
Byun, Mi Ran ; Kim, A. Rum ; Hwang, Jun Ha ; Sung, Mi Kyung ; Lee, Yeon Kyung ; Hwang, Buyng Su ; Rho, Jung Rae ; Hwang, Eun Sook ; Hong, Jeong-Ho. / Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation. In: FEBS Letters. 2012 ; Vol. 586, No. 8. pp. 1086-1092.
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