Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation

Jung Rae Rho, Buyng Su Hwang, Seewon Joung, Mi Ran Byun, Jeong-Ho Hong, Hee Yoon Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.(Figure Presented)

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
Publication statusPublished - 2011 Mar 4

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osteoblasts
Osteoblasts
Porifera
calcium
chemical reactions
induction
carbon
Military Personnel
cells
Chemical reactions
Carbon
Calcium
phorbasone A
phorbasone B

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation. / Rho, Jung Rae; Hwang, Buyng Su; Joung, Seewon; Byun, Mi Ran; Hong, Jeong-Ho; Lee, Hee Yoon.

In: Organic Letters, Vol. 13, No. 5, 04.03.2011, p. 884-887.

Research output: Contribution to journalArticle

Rho, Jung Rae ; Hwang, Buyng Su ; Joung, Seewon ; Byun, Mi Ran ; Hong, Jeong-Ho ; Lee, Hee Yoon. / Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation. In: Organic Letters. 2011 ; Vol. 13, No. 5. pp. 884-887.
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