Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation

Jung Rae Rho, Buyng Su Hwang, Seewon Joung, Mi Ran Byun, Jeong Ho Hong, Hee Yoon Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.(Figure Presented)

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
Publication statusPublished - 2011 Mar 4

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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