Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation

Jung Rae Rho, Buyng Su Hwang, Seewon Joung, Mi Ran Byun, Jeong-Ho Hong, Hee Yoon Lee

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20 Citations (Scopus)


Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.(Figure Presented)

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalOrganic Letters
Issue number5
Publication statusPublished - 2011 Mar 4


ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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