Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

Soon Young Shin, Ha Young Choi, Bong Hyun Ahn, Do Sik Min, Sang Wook Son, Young Han Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume353
Issue number3
DOIs
Publication statusPublished - 2007 Feb 16

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Keywords

  • MAPK
  • MMP-3
  • PLCγ1
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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