Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

Soon Young Shin, Ha Young Choi, Bong Hyun Ahn, Do Sik Min, Sang Wook Son, Young Han Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume353
Issue number3
DOIs
Publication statusPublished - 2007 Feb 16

Fingerprint

Matrix Metalloproteinase 3
Protein Kinase C
Transcriptional Activation
Tumors
Genes
Chemical activation
Neoplasms
Proteins
Neoplasm Metastasis
Cell proliferation
Hydrolases
Matrix Metalloproteinases
Cell Movement
Phospholipids
Cell Proliferation
Modulation
phospholipase C1

Keywords

  • MAPK
  • MMP-3
  • PLCγ1
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade. / Shin, Soon Young; Choi, Ha Young; Ahn, Bong Hyun; Min, Do Sik; Son, Sang Wook; Lee, Young Han.

In: Biochemical and Biophysical Research Communications, Vol. 353, No. 3, 16.02.2007, p. 611-616.

Research output: Contribution to journalArticle

@article{5ff09adda0864607a55ae0b73601928c,
title = "Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade",
abstract = "The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.",
keywords = "MAPK, MMP-3, PLCγ1, Protein kinase C",
author = "Shin, {Soon Young} and Choi, {Ha Young} and Ahn, {Bong Hyun} and Min, {Do Sik} and Son, {Sang Wook} and Lee, {Young Han}",
year = "2007",
month = "2",
day = "16",
doi = "10.1016/j.bbrc.2006.12.064",
language = "English",
volume = "353",
pages = "611--616",
journal = "The BMJ",
issn = "0730-6512",
publisher = "Kluwer Academic Publishers",
number = "3",

}

TY - JOUR

T1 - Phospholipase Cγ1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade

AU - Shin, Soon Young

AU - Choi, Ha Young

AU - Ahn, Bong Hyun

AU - Min, Do Sik

AU - Son, Sang Wook

AU - Lee, Young Han

PY - 2007/2/16

Y1 - 2007/2/16

N2 - The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

AB - The phospholipid hydrolase phospholipase Cγ1 (PLCγ1) plays a major role in regulation of cell proliferation, development, and cell motility. Overexpression of PLCγ1 is associated with tumor development, and it is overexpressed in some tumors. Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. Here, we demonstrate that overexpression of PLCγ1 stimulates MMP-3 expression at the transcriptional level via the PKC-mediated Raf/MEK1/ERK signaling cascade. We propose that modulation of PLCγ1 activity might be of value in controlling the activity of MMPs, which are important regulators of invasion and metastasis in malignant tumors.

KW - MAPK

KW - MMP-3

KW - PLCγ1

KW - Protein kinase C

UR - http://www.scopus.com/inward/record.url?scp=33846000588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846000588&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2006.12.064

DO - 10.1016/j.bbrc.2006.12.064

M3 - Article

VL - 353

SP - 611

EP - 616

JO - The BMJ

JF - The BMJ

SN - 0730-6512

IS - 3

ER -