Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells

Hee Jung Yang, Hyesook Youn, Ki Moon Seong, Young Woo Jin, Joon Kim, Buhyun Youn

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Radioresistance is a critical factor restricting efficacy of radiotherapy. Results: Phosphorylation of both rpS3 and TRAF2 induces dissociation of rpS3-TRAF2 complex and influences radioresistance through activation of NF-κB pathway. Conclusion: Phosphorylation of rpS3 and TRAF2 is a key control point of radioresistance in NSCLC cells. Significant: Our findings reveal a novel radioresistance mechanism through functional orchestration of rpS3, TRAF2, and NF-κB in NSCLC cells.

Original languageEnglish
Pages (from-to)2965-2975
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number5
DOIs
Publication statusPublished - 2013 Feb 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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