Photobiomodulation of extracellular matrix enzymes in human nucleus pulposus cells as a potential treatment for intervertebral disk degeneration

Min Ho Hwang, Hyeong Guk Son, Jae Won Lee, Chang Min Yoo, Jae Hee Shin, Hyo Geun Nam, Hyun Jung Lim, Seung Min Baek, Jeong Hun Park, Joo-Han Kim, Hyuk Choi

Research output: Contribution to journalArticle

Abstract

Intervertebral disc (IVD) degeneration is associated with imbalances between catabolic and anabolic responses, regulated by extracellular matrix (ECM)-modifying enzymes such as matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors of metalloproteinases (TIMPs). Potential contributing factors, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α, derived from infiltrated, activated macrophages within IVD tissues, can trigger abnormal production of ECM-modifying enzymes and progression of IVD degeneration. Novel therapies for regulating ECM-modifying enzymes can prevent or ameliorate IVD degeneration. Photobiomodulation (PBM), known to regulate wound repair, exhibits regenerative potential by modulating biological molecules. This study examined the effects of PBM, administered at various wavelengths (630, 525, and 465 nm) and energy densities (16, 32, and 64 J/cm2), on the production of ECM-modifying enzymes in replicated degenerative IVD. Our results showed that PBM selectively inhibited the production of ECM-modifying enzymes in a dose- and wavelength-dependent manner, suggesting that it could be a novel tool for treating symptomatic IVD degeneration.

Original languageEnglish
Article number11654
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Intervertebral Disc Degeneration
Extracellular Matrix
Enzymes
Tissue Inhibitor of Metalloproteinases
Intervertebral Disc
Matrix Metalloproteinases
Interleukin-1
Tumor Necrosis Factor-alpha
Macrophages
Nucleus Pulposus
Wounds and Injuries

ASJC Scopus subject areas

  • General

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Photobiomodulation of extracellular matrix enzymes in human nucleus pulposus cells as a potential treatment for intervertebral disk degeneration. / Hwang, Min Ho; Son, Hyeong Guk; Lee, Jae Won; Yoo, Chang Min; Shin, Jae Hee; Nam, Hyo Geun; Lim, Hyun Jung; Baek, Seung Min; Park, Jeong Hun; Kim, Joo-Han; Choi, Hyuk.

In: Scientific Reports, Vol. 8, No. 1, 11654, 01.12.2018.

Research output: Contribution to journalArticle

Hwang, Min Ho ; Son, Hyeong Guk ; Lee, Jae Won ; Yoo, Chang Min ; Shin, Jae Hee ; Nam, Hyo Geun ; Lim, Hyun Jung ; Baek, Seung Min ; Park, Jeong Hun ; Kim, Joo-Han ; Choi, Hyuk. / Photobiomodulation of extracellular matrix enzymes in human nucleus pulposus cells as a potential treatment for intervertebral disk degeneration. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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