Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Yong Doo Park, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD.

Original languageEnglish
Pages (from-to)893-900
Number of pages8
JournalBiomaterials
Volume24
Issue number6
DOIs
Publication statusPublished - 2003 Mar

Keywords

  • Cell adhesion
  • Hyaluronic acid
  • Hydrogels
  • Photopolymerization
  • RGD

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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