Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Yongdoo Park, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD.

Original languageEnglish
Pages (from-to)893-900
Number of pages8
JournalBiomaterials
Volume24
Issue number6
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Hyaluronic acid
Hydrogels
Interpenetrating polymer networks
Hyaluronic Acid
Polyethylene glycols
Molecular Weight
Molecular weight
Hyaluronoglucosaminidase
Photopolymerization
Elastic Modulus
Fibroblasts
Adhesives
Peptides
Swelling
Esters
Adhesion
Elastic moduli
Modulation
Mechanical properties
Skin

Keywords

  • Cell adhesion
  • Hyaluronic acid
  • Hydrogels
  • Photopolymerization
  • RGD

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. / Park, Yongdoo; Tirelli, Nicola; Hubbell, Jeffrey A.

In: Biomaterials, Vol. 24, No. 6, 2003, p. 893-900.

Research output: Contribution to journalArticle

Park, Yongdoo ; Tirelli, Nicola ; Hubbell, Jeffrey A. / Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks. In: Biomaterials. 2003 ; Vol. 24, No. 6. pp. 893-900.
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