Photoprotective effects of galacto-oligosaccharide and/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice

Ki Bae Hong, Mingeum Jeong, Ki Soo Han, Jae Hwan Kim, Yooheon Park, Hyung Joo Suh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study aimed at examining whether oral administration of galacto-oligosaccharide (GOS) and Bifidobacterium longum, individually or in combination, could exert photoprotective effects on the skin of hairless mice. GOS and/or Bifidobacterium were administered orally to hairless mice for 12 weeks. Mice were irradiated with UV light daily for four consecutive days. GOS administration increased the water-holDing capacity of the skin and prevented transepidermal water loss compared with the control. A reduction in the erythema formation of 16.8% was also observed in the GOS-treated group compared with the control, and CD44 gene expression was significantly increased. Oral administration of GOS or Bifidobacterium significantly increased TIMP-1 and Col1 mRNA expression compared with the control. Our findings support that prebiotics, incluDing GOS, are beneficial not only to the intestine, but also to the skin, and present the possibility of new nutritional strategies for the prevention of UV-induced skin damage.

Original languageEnglish
Pages (from-to)923-930
Number of pages8
JournalInternational Journal of Food Sciences and Nutrition
Volume66
Issue number8
DOIs
Publication statusPublished - 2015 Nov 17

Fingerprint

galactooligosaccharides
Hairless Mouse
Bifidobacterium longum
Oligosaccharides
irradiation
Skin
mice
Bifidobacterium
oral administration
Oral Administration
Prebiotics
erythema
Tissue Inhibitor of Metalloproteinase-1
Water
Erythema
prebiotics
Ultraviolet Rays
water holding capacity
Intestines
ultraviolet radiation

Keywords

  • Bifidobacterium longum
  • Galacto-oligosaccharide
  • Photoprotective activity
  • Skin damage
  • Water-holDing capacity

ASJC Scopus subject areas

  • Food Science

Cite this

Photoprotective effects of galacto-oligosaccharide and/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice. / Hong, Ki Bae; Jeong, Mingeum; Han, Ki Soo; Hwan Kim, Jae; Park, Yooheon; Suh, Hyung Joo.

In: International Journal of Food Sciences and Nutrition, Vol. 66, No. 8, 17.11.2015, p. 923-930.

Research output: Contribution to journalArticle

@article{6840a45d8a524182b3fb623ae6398ae9,
title = "Photoprotective effects of galacto-oligosaccharide and/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice",
abstract = "This study aimed at examining whether oral administration of galacto-oligosaccharide (GOS) and Bifidobacterium longum, individually or in combination, could exert photoprotective effects on the skin of hairless mice. GOS and/or Bifidobacterium were administered orally to hairless mice for 12 weeks. Mice were irradiated with UV light daily for four consecutive days. GOS administration increased the water-holDing capacity of the skin and prevented transepidermal water loss compared with the control. A reduction in the erythema formation of 16.8{\%} was also observed in the GOS-treated group compared with the control, and CD44 gene expression was significantly increased. Oral administration of GOS or Bifidobacterium significantly increased TIMP-1 and Col1 mRNA expression compared with the control. Our findings support that prebiotics, incluDing GOS, are beneficial not only to the intestine, but also to the skin, and present the possibility of new nutritional strategies for the prevention of UV-induced skin damage.",
keywords = "Bifidobacterium longum, Galacto-oligosaccharide, Photoprotective activity, Skin damage, Water-holDing capacity",
author = "Hong, {Ki Bae} and Mingeum Jeong and Han, {Ki Soo} and {Hwan Kim}, Jae and Yooheon Park and Suh, {Hyung Joo}",
year = "2015",
month = "11",
day = "17",
doi = "10.3109/09637486.2015.1088823",
language = "English",
volume = "66",
pages = "923--930",
journal = "International Journal of Food Sciences and Nutrition",
issn = "0963-7486",
publisher = "Informa Healthcare",
number = "8",

}

TY - JOUR

T1 - Photoprotective effects of galacto-oligosaccharide and/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice

AU - Hong, Ki Bae

AU - Jeong, Mingeum

AU - Han, Ki Soo

AU - Hwan Kim, Jae

AU - Park, Yooheon

AU - Suh, Hyung Joo

PY - 2015/11/17

Y1 - 2015/11/17

N2 - This study aimed at examining whether oral administration of galacto-oligosaccharide (GOS) and Bifidobacterium longum, individually or in combination, could exert photoprotective effects on the skin of hairless mice. GOS and/or Bifidobacterium were administered orally to hairless mice for 12 weeks. Mice were irradiated with UV light daily for four consecutive days. GOS administration increased the water-holDing capacity of the skin and prevented transepidermal water loss compared with the control. A reduction in the erythema formation of 16.8% was also observed in the GOS-treated group compared with the control, and CD44 gene expression was significantly increased. Oral administration of GOS or Bifidobacterium significantly increased TIMP-1 and Col1 mRNA expression compared with the control. Our findings support that prebiotics, incluDing GOS, are beneficial not only to the intestine, but also to the skin, and present the possibility of new nutritional strategies for the prevention of UV-induced skin damage.

AB - This study aimed at examining whether oral administration of galacto-oligosaccharide (GOS) and Bifidobacterium longum, individually or in combination, could exert photoprotective effects on the skin of hairless mice. GOS and/or Bifidobacterium were administered orally to hairless mice for 12 weeks. Mice were irradiated with UV light daily for four consecutive days. GOS administration increased the water-holDing capacity of the skin and prevented transepidermal water loss compared with the control. A reduction in the erythema formation of 16.8% was also observed in the GOS-treated group compared with the control, and CD44 gene expression was significantly increased. Oral administration of GOS or Bifidobacterium significantly increased TIMP-1 and Col1 mRNA expression compared with the control. Our findings support that prebiotics, incluDing GOS, are beneficial not only to the intestine, but also to the skin, and present the possibility of new nutritional strategies for the prevention of UV-induced skin damage.

KW - Bifidobacterium longum

KW - Galacto-oligosaccharide

KW - Photoprotective activity

KW - Skin damage

KW - Water-holDing capacity

UR - http://www.scopus.com/inward/record.url?scp=84959332182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959332182&partnerID=8YFLogxK

U2 - 10.3109/09637486.2015.1088823

DO - 10.3109/09637486.2015.1088823

M3 - Article

C2 - 26470918

AN - SCOPUS:84959332182

VL - 66

SP - 923

EP - 930

JO - International Journal of Food Sciences and Nutrition

JF - International Journal of Food Sciences and Nutrition

SN - 0963-7486

IS - 8

ER -