Phthalocyanine-aggregated polymeric nanoparticles as tumor-homing near-infrared absorbers for photothermal therapy of cancer

Chang Keun Lim, Jiyoung Shin, Yong Deok Lee, Jungahn Kim, Keun Sang Oh, Soon Hong Yuk, Seo Young Jeong, Ick Chan Kwon, Sehoon Kim

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Phthalocyanine-aggregated Pluronic nanoparticles were constructed as a novel type of near-infrared (NIR) absorber for photothermal therapy. Tiny nanoparticles (~ 60 nm, FPc NPs) were prepared by aqueous dispersion of phthalocyanine-aggregated self-assembled nanodomains that were phase-separated from the melt mixture with Pluronic. Under NIR laser irradiation, FPc NPs manifested robust heat generation capability, superior to an indi-vidual cyanine dye and cyanine-aggregated nanoparticles. Micro- and macroscopic imaging experiments showed that FPc NPs are capable of internalization into live cancer cells as well as tumor accumulation when intravenously administered into living mice. It is shown here that continuous NIR irradiation of the tumor-targeted FPc NPs can cause phototherapeutic effects in vitro and in vivo through excessive local heating, demonstrating potential of phthalocya-nine-aggregated nanoparticles as an all-organic NIR nanoabsorber for hyperthermia.

Original languageEnglish
Pages (from-to)871-879
Number of pages9
JournalTheranostics
Volume2
Issue number9
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

Keywords

  • Hy-perthermia
  • Nanoparticles
  • Near-infrared photonics
  • Phototermal therapy
  • Phthalocyanine
  • Tumor targeting

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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