Physeal cartilage exhibits rapid consolidation and recovery in intact knees that are physiologically loaded

Yongnam Song, Dokwan Lee, Choongsoo S. Shin, Dennis R. Carter, Nicholas J. Giori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The growth plate (physis) is responsible for long bone growth through endochondral ossification, a process which can be mechanically modulated. However, our understanding of the detailed mechanical behavior of physeal cartilage occurring in vivo is limited. In this study, we aimed to quantify the time-dependent deformational behavior of physeal cartilage in intact knees under physiologically realistic dynamic loading, and compare physeal cartilage deformation with articular cartilage deformation. A 4.7T MRI scanner continuously scanned a knee joint in the sagittal plane through the central load-bearing region of the medial compartment every 2.5. min while a realistic cyclic loading was applied. A custom auto-segmentation program was developed to delineate complex physeal cartilage boundaries. Physeal volume changes at each time step were calculated. The new auto-segmentation was found to be reproducible with COV of the volume measurements being less than 0.5%. Time-constants of physeal cartilage consolidation (1.31±0.74. min) and recovery (1.63±0.70. min) were significantly smaller than the values (5.53±1.78/17.71±13.88. min for consolidation/recovery) in articular cartilage (P<0.05). The rapid consolidation and recovery of physeal cartilage may due to a relatively free metaphyseal fluid boundary which would allow rapid fluid exchange with the adjacent cancellous bone. This may impair the generation of hydrostatic pressure in the cartilage matrix when the physis is under chronic compressive loading, and may be related to the premature ossification of the growth plate under such conditions. Research on the growth plate fluid exchange may provide a more comprehensive understanding of mechanisms and disorders of long bone growth.

Original languageEnglish
Pages (from-to)1516-1523
Number of pages8
JournalJournal of Biomechanics
Volume46
Issue number9
DOIs
Publication statusPublished - 2013 May 31

Fingerprint

Cartilage
Consolidation
Knee
Recovery
Growth Plate
Bone Development
Articular Cartilage
Osteogenesis
Bone
Fluids
Bearings (structural)
Hydrostatic Pressure
Weight-Bearing
Knee Joint
Volume measurement
Hydrostatic pressure
Magnetic resonance imaging
Research

Keywords

  • Articular cartilage
  • Dynamic deformation
  • Fluid boundary condition
  • Growth plate
  • Mechanical stimulation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

Physeal cartilage exhibits rapid consolidation and recovery in intact knees that are physiologically loaded. / Song, Yongnam; Lee, Dokwan; Shin, Choongsoo S.; Carter, Dennis R.; Giori, Nicholas J.

In: Journal of Biomechanics, Vol. 46, No. 9, 31.05.2013, p. 1516-1523.

Research output: Contribution to journalArticle

Song, Yongnam ; Lee, Dokwan ; Shin, Choongsoo S. ; Carter, Dennis R. ; Giori, Nicholas J. / Physeal cartilage exhibits rapid consolidation and recovery in intact knees that are physiologically loaded. In: Journal of Biomechanics. 2013 ; Vol. 46, No. 9. pp. 1516-1523.
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