Physical activity frequency and the risk of stroke: A nationwide cohort study in Korea

Han Gil Jeong, Do Yeon Kim, Dong Wan Kang, Beom Joon Kim, Chi Kyung Kim, Yerim Kim, Wookjin Yang, Eun Sun Park, Seung Hoon Lee

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Abstract

Background--The current guideline recommends moderate- to vigorous-intensity physical activity (PA) at least 40 min/day for 3 to 4 days/week. Although recent evidence has demonstrated that low-dose PA could reduce cardiovascular mortality, the relationship between low-dose PA and the risk of stroke remains uncertain. Methods and Results--Using data from a nation-wide sample cohort in Korea, we examined 336 326 individuals who received a general health examination between 2009 and 2010. Level of PA was assessed using a questionnaire for weekly PA frequencies regarding 3 intensity categories: light, moderate, and vigorous. Moderate- to vigorous-intensity PA (MVPA) was classified into 4 frequency categories: none, 1 to 2, 3 to 4, or ≥5 times/week. Cox proportional hazard models were constructed to estimate the risk of stroke. During the average follow-up of 3.6 years, 2213 stroke cases occurred. MVPA was none in 50%, 1 to 2 times/week in 20%, 3 to 4 times/week in 13%, and ≥5 times/week in 18% of the cohort. Individuals with MVPA 1 to 2 times/week had a 16% reduced risk of stroke (adjusted hazard ratio, 0.84; 95% confidence interval, 0.73-0.96) compared with those with no MVPA. The population attributable fraction of no MVPA was 12%, which was the second most important risk factor for a stroke after hypertension. Conclusions--Even 1 to 2 times a week of MVPA might be beneficial to prevent a first-ever stroke in the general population, although a quantitative validation of the questionnaire is needed. From a public health perspective, we need to encourage inactive people to start exercising with more-achievable goals.

Original languageEnglish
Article numbere005671
JournalJournal of the American Heart Association
Volume6
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

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Keywords

  • Physical activity
  • Primary prevention
  • Risk factor
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Jeong, H. G., Kim, D. Y., Kang, D. W., Kim, B. J., Kim, C. K., Kim, Y., Yang, W., Park, E. S., & Lee, S. H. (2017). Physical activity frequency and the risk of stroke: A nationwide cohort study in Korea. Journal of the American Heart Association, 6(9), [e005671]. https://doi.org/10.1161/JAHA.117.005671