Abstract
Objectives: To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity. Methods: Data from the 1958 British birth cohort (n= 7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45. y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45. y. Results: Activity at different ages was associated with HDL-cholesterol and triglycerides at 45. y: e.g. in men, a 1 day/week greater activity frequency at 42. y was associated with 0.006. mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33. y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45. y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1. h/day greater sitting among men was associated with a 0.012. mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04. mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45. y, attenuated, respectively, to 0.03. mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent. Conclusion: Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI.
| Original language | English |
|---|---|
| Pages (from-to) | 361-367 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 219 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Nov 1 |
| Externally published | Yes |
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Keywords
- Birth cohort
- Lipids
- Physical activity
- Sedentary behaviour
- TV-viewing
- Work activity
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Physical (in)activity over 20y in adulthood : Associations with adult lipid levels in the 1958 British birth cohort. / Ki, Myung; Pouliou, Theodora; Li, Leah; Power, Chris.
In: Atherosclerosis, Vol. 219, No. 1, 01.11.2011, p. 361-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physical (in)activity over 20y in adulthood
T2 - Associations with adult lipid levels in the 1958 British birth cohort
AU - Ki, Myung
AU - Pouliou, Theodora
AU - Li, Leah
AU - Power, Chris
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Objectives: To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity. Methods: Data from the 1958 British birth cohort (n= 7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45. y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45. y. Results: Activity at different ages was associated with HDL-cholesterol and triglycerides at 45. y: e.g. in men, a 1 day/week greater activity frequency at 42. y was associated with 0.006. mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33. y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45. y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1. h/day greater sitting among men was associated with a 0.012. mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04. mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45. y, attenuated, respectively, to 0.03. mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent. Conclusion: Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI.
AB - Objectives: To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity. Methods: Data from the 1958 British birth cohort (n= 7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45. y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45. y. Results: Activity at different ages was associated with HDL-cholesterol and triglycerides at 45. y: e.g. in men, a 1 day/week greater activity frequency at 42. y was associated with 0.006. mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33. y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45. y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1. h/day greater sitting among men was associated with a 0.012. mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04. mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45. y, attenuated, respectively, to 0.03. mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent. Conclusion: Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI.
KW - Birth cohort
KW - Lipids
KW - Physical activity
KW - Sedentary behaviour
KW - TV-viewing
KW - Work activity
UR - http://www.scopus.com/inward/record.url?scp=80054974907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054974907&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2011.07.109
DO - 10.1016/j.atherosclerosis.2011.07.109
M3 - Article
VL - 219
SP - 361
EP - 367
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -