Physical properties of covered stent in gastric acid environment: In Vitro study

Sung Chul Park, Nark Soon Park, Dong Gon Kim, Jae Woon Nah, Yoon Tae Jeen, Hye Jin Cho, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    In membrane covered stent, occlusion and fracture from membrane degradation by gastric acid sometimes occurred. Therefore, we investigated the physical properties of membrane covered stent according to its ingredient and concentration in gastric acid environment. Membrane covered stents consisted of silicone and polyurethane with 15%, 18%, 20% concentrations were used. After incubating stents in a condition of pH 1.2, we checked any changes at every 3 weeks for 18 weeks. The changes of membrane surface, radial expansion and recovery force of stent were investigated. Coating thickness increased proportionally to an increase in ingredient concentration. Surface was evenly coated with silicone compared to the case with polyurethane and its homogeneity was excellent in a high concentration. Degradation was much severe in the case of polyurethane. The radial force of silicone was higher than polyurethane, and the decrease of radial and recovery force was higher in the case of polyurethane. In conclusion, high concentration of silicone membrane was more stable than polyurethane in acid environment of in vitro study.

    Original languageEnglish
    Pages (from-to)351-357
    Number of pages7
    JournalPolymer (Korea)
    Volume38
    Issue number3
    DOIs
    Publication statusPublished - 2014 May

    Keywords

    • Covered stent
    • Gastric acid
    • Physical property
    • Polyurethane
    • Silicone

    ASJC Scopus subject areas

    • Chemical Engineering(all)
    • Polymers and Plastics
    • Materials Chemistry

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