Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans

Kuen Yong Lee, Won Ho Jo, Ick Chan Kwon, Yong Hee Kim, Seo Young Jeong

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Chitosan derivatives containing 2.8-5.1 deoxycholic acid groups per 100 anhydroglucosamine units of chitosan were synthesized by an EDC-mediated coupling reaction. Physicochemical properties of self-aggregates of the hydrophobically modified chitosans in aqueous media were studied by the dynamic light scattering method and fluorescence spectroscopy. The mean diameter (dH) of DC4.2 self-aggregates in phosphate-buffered saline (PBS) solution (pH 7.2) was 159 nm with unimodal size distribution (variance = 0.082). It seemed that the interparticle interaction between self-aggregates was almost negligible. The mean diameter decreased with increasing degree of substitution (DS), pH, or ionic strength of the medium. The critical aggregation concentration (cac) of self-aggregates was determined from the fluorescence emission spectra of pyrene. The cac value of DC4.2 in PBS solution (pH 7.2) was 2.6 × 10-2 mg/mL. The cac values decreased with increasing DS, pH, or ionic strength of the medium.

Original languageEnglish
Pages (from-to)2329-2332
Number of pages4
JournalLangmuir
Volume14
Issue number9
Publication statusPublished - 1998 Apr 28
Externally publishedYes

Fingerprint

Chitosan
Agglomeration
Ionic strength
Sodium Chloride
Osmolar Concentration
phosphates
Phosphates
Substitution reactions
substitutes
fluorescence
Deoxycholic Acid
Fluorescence Spectrometry
Pyrene
Fluorescence spectroscopy
pyrenes
Dynamic light scattering
emission spectra
light scattering
Fluorescence
Derivatives

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

Cite this

Lee, K. Y., Jo, W. H., Kwon, I. C., Kim, Y. H., & Jeong, S. Y. (1998). Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans. Langmuir, 14(9), 2329-2332.

Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans. / Lee, Kuen Yong; Jo, Won Ho; Kwon, Ick Chan; Kim, Yong Hee; Jeong, Seo Young.

In: Langmuir, Vol. 14, No. 9, 28.04.1998, p. 2329-2332.

Research output: Contribution to journalArticle

Lee, KY, Jo, WH, Kwon, IC, Kim, YH & Jeong, SY 1998, 'Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans', Langmuir, vol. 14, no. 9, pp. 2329-2332.
Lee KY, Jo WH, Kwon IC, Kim YH, Jeong SY. Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans. Langmuir. 1998 Apr 28;14(9):2329-2332.
Lee, Kuen Yong ; Jo, Won Ho ; Kwon, Ick Chan ; Kim, Yong Hee ; Jeong, Seo Young. / Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans. In: Langmuir. 1998 ; Vol. 14, No. 9. pp. 2329-2332.
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