Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans

Kuen Yong Lee, Won Ho Jo, Ick Chan Kwon, Yong Hee Kim, Seo Young Jeong

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Abstract

Chitosan derivatives containing 2.8-5.1 deoxycholic acid groups per 100 anhydroglucosamine units of chitosan were synthesized by an EDC-mediated coupling reaction. Physicochemical properties of self-aggregates of the hydrophobically modified chitosans in aqueous media were studied by the dynamic light scattering method and fluorescence spectroscopy. The mean diameter (dH) of DC4.2 self-aggregates in phosphate-buffered saline (PBS) solution (pH 7.2) was 159 nm with unimodal size distribution (variance = 0.082). It seemed that the interparticle interaction between self-aggregates was almost negligible. The mean diameter decreased with increasing degree of substitution (DS), pH, or ionic strength of the medium. The critical aggregation concentration (cac) of self-aggregates was determined from the fluorescence emission spectra of pyrene. The cac value of DC4.2 in PBS solution (pH 7.2) was 2.6 × 10-2 mg/mL. The cac values decreased with increasing DS, pH, or ionic strength of the medium.

Original languageEnglish
Pages (from-to)2329-2332
Number of pages4
JournalLangmuir
Volume14
Issue number9
Publication statusPublished - 1998 Apr 28

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Lee, K. Y., Jo, W. H., Kwon, I. C., Kim, Y. H., & Jeong, S. Y. (1998). Physicochemical characteristics of self-aggregates of hydrophobically modified chitosans. Langmuir, 14(9), 2329-2332.