Physicochemical properties of surface charge-modified ZnO nanoparticles with different particle sizes

Kyoung Min Kim, Mun Hyoung Choi, Jong Kwon Lee, Jayoung Jeong, Yu Ri Kim, Meyoung Kon Kim, Seung Min Paek, Jae Min Oh

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


In this study, four types of standardized ZnO nanoparticles were prepared for assessment of their potential biological risk. Powder-phased ZnO nanoparticles with different particle sizes (20 nm and 100 nm) were coated with citrate or L-serine to induce a negative or positive surface charge, respectively. The four types of coated ZnO nanoparticles were subjected to physicochemical evaluation according to the guidelines published by the Organisation for Economic Cooperation and Development. All four samples had a well crystallized Wurtzite phase, with particle sizes of ∼30 nm and ∼70 nm after coating with organic molecules. The coating agents were determined to have attached to the ZnO surfaces through either electrostatic interaction or partial coordination bonding. Electrokinetic measurements showed that the surface charges of the ZnO nanoparticles were successfully modified to be negative (about -40 mV) or positive (about +25 mV). Although all the four types of ZnO nanoparticles showed some agglomeration when suspended in water according to dynamic light scattering analysis, they had clearly distinguishable particle size and surface charge parameters and well defined physicochemical properties.

Original languageEnglish
Pages (from-to)41-56
Number of pages16
JournalInternational Journal of Nanomedicine
Publication statusPublished - 2014 Dec 15
Externally publishedYes


  • Particle size
  • Physicochemical properties
  • Surface charge
  • Surface coating
  • ZnO nanoparticles

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Physicochemical properties of surface charge-modified ZnO nanoparticles with different particle sizes'. Together they form a unique fingerprint.

Cite this