TY - JOUR
T1 - Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells
AU - Xu, Jing
AU - Sun, Xiaocong
AU - Liu, Xingyu
AU - Peng, Maoqin
AU - Li, Shen
AU - Jin, Da Qing
AU - Lee, Dongho
AU - Bartlam, Mark
AU - Guo, Yuanqiang
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 21372125 ) and the Ministry of Science & Technology 973 Project (No. 2014CB560709 ).
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A-D (1-4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food.
AB - Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A-D (1-4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food.
KW - Alkaloids
KW - Chroman
KW - Melicope pteleifolia
KW - Neurite outgrowth
KW - Quinoline
UR - http://www.scopus.com/inward/record.url?scp=84962272550&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2016.03.011
DO - 10.1016/j.jff.2016.03.011
M3 - Article
AN - SCOPUS:84962272550
SN - 1756-4646
VL - 23
SP - 565
EP - 572
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -