Phytochemical constituents from Melicope pteleifolia that promote neurite outgrowth in PC12 cells

Jing Xu, Xiaocong Sun, Xingyu Liu, Maoqin Peng, Shen Li, Da Qing Jin, Dongho Lee, Mark Bartlam, Yuanqiang Guo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A-D (1-4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food.

Original languageEnglish
Pages (from-to)565-572
Number of pages8
JournalJournal of Functional Foods
Volume23
DOIs
Publication statusPublished - 2016 May 1

Keywords

  • Alkaloids
  • Chroman
  • Melicope pteleifolia
  • Neurite outgrowth
  • Quinoline

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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