PI3K/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae).

Jae-Hong Kim, J. S. Choi, B. H. Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The Forkhead box O (FoxO) transcription factors, including FoxO1, FoxO3a, FoxO4, and FoxO6, are implicated in the regulation of cell apoptosis and survival. Here, we examined the role of FoxO transcription factors and the involvement of the PI3K/Akt and mitogen-activated protein kinase (MAPK) pathways in neuronal apoptosis in the brain of the silkworm Bombyx mori following starvation. Starvation inhibited cell proliferation and induced apoptosis through caspase-3 activation. The level of phosphorylated kinase Akt increased when the animals ceased feeding. Starvation conditions reduced extracellular-signal-regulated kinase phosphorylation but increased both c-Jun N-terminal kinase and p38 (MAPK) phosphorylation. FoxO1 and FoxO3a were simultaneously localized in the nuclei. These results provide new insights into the process of apoptosis of brain neurons through the involvement of FoxO transcription factors following starvation of insect species.

Original languageEnglish
JournalCellular and molecular biology (Noisy-le-Grand, France)
VolumeSuppl.58
Publication statusPublished - 2012 Dec 1

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Forkhead Transcription Factors
Lepidoptera
Bombyx
Starvation
Mitogen-Activated Protein Kinases
Phosphatidylinositol 3-Kinases
Brain
Transcription Factors
Chemical activation
Apoptosis
Phosphorylation
JNK Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
Cell proliferation
p38 Mitogen-Activated Protein Kinases
Caspase 3
Neurons
Insects
Cell Survival
Animals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The Forkhead box O (FoxO) transcription factors, including FoxO1, FoxO3a, FoxO4, and FoxO6, are implicated in the regulation of cell apoptosis and survival. Here, we examined the role of FoxO transcription factors and the involvement of the PI3K/Akt and mitogen-activated protein kinase (MAPK) pathways in neuronal apoptosis in the brain of the silkworm Bombyx mori following starvation. Starvation inhibited cell proliferation and induced apoptosis through caspase-3 activation. The level of phosphorylated kinase Akt increased when the animals ceased feeding. Starvation conditions reduced extracellular-signal-regulated kinase phosphorylation but increased both c-Jun N-terminal kinase and p38 (MAPK) phosphorylation. FoxO1 and FoxO3a were simultaneously localized in the nuclei. These results provide new insights into the process of apoptosis of brain neurons through the involvement of FoxO transcription factors following starvation of insect species.",
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AU - Lee, B. H.

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