Picolinafen exerts developmental toxicity via the suppression of oxidative stress and angiogenesis in zebrafish embryos

Jin Young Lee, Sunwoo Park, Whasun Lim, Gwonhwa Song

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Picolinafen, a phytoene desaturase-inhibiting herbicide, has been used since 2001 to control the growth of broadleaf weeds. Picolinafen has lower solubility and volatility, and shows lower toxicity to non-target insect species than other types of herbicide. Although picolinafen has been detected in lakes near urban environments and induces chronic toxicity in the mammals, birds, and some aquatic organisms, no study has investigated the toxicity or mode of action of picolinafen in zebrafish. In this study, we demonstrated the lethality and acute LC50 value of picolinafen towards zebrafish embryos. Picolinafen hampered the development of embryos by the induction of morphological abnormalities via apoptosis. Additionally, picolinafen suppressed the generation of reactive oxygen species and angiogenesis. Also, the angiogenesis related genes, flt1 and flt4 mRNA expression was decreased in zebrafish embryos. This study provides a mechanistic understanding of the developmental toxicity of picolinafen in vertebrates.

Original languageEnglish
Article number104734
JournalPesticide Biochemistry and Physiology
Volume171
DOIs
Publication statusPublished - 2021 Jan

Keywords

  • Angiogenesis
  • Developmental toxicity
  • Oxidative stress
  • Picolinafen
  • Zebrafish

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Health, Toxicology and Mutagenesis

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