Pioglitazone increases circulating microRNA-24 with decrease in coronary neointimal hyperplasia in type 2 diabetic patients: Optical coherence tomography analysis

Soon Jun Hong, Seung Cheol Choi, Jae Young Cho, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do Sun Lim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Aberrant expression of microRNAs is associated with neointimal hyperplasia (NIH) in type 2 diabetes. We prospectively compared the effects of pioglitazone on coronary NIH and changes in microRNAs according to NIH status in type 2 diabetic patients during 9-month follow-up. Methods and Results: Type 2 diabetic patients were randomly assigned to the pioglitazone (n=36) or control groups (n=36) after coronary stenting. Primary endpoint was the comparison of changes in neointimal volume on OCT and in the level of circulating microRNA-17,-24,-92a,-126 and -145 during 9-month follow-up. Secondary endpoint was the comparison of changes in brachial artery flow-mediated dilation and inflammatory markers such as IL-6, TNF-α, hsCRP, adiponectin, sICAM-1, and sVCAM-1 between the 2 groups. Neointimal volume was significantly lower in the pioglitazone group (25.02±17.78 mm3 vs. 55.10±30.01 mm3, P<0.001) with significant increases in circulating microRNA-24 (0.264±0.084 vs. 0.006±0.030, P<0.001) during follow-up. FMD was significantly greater in the pioglitazone than control group at 9 months (0.47±0.14 mm vs. 0.28±0.18 mm, P<0.05, respectively). Decreases in inflammatory markers such as IL-6, TNF-α, and sVCAM-1 were significantly greater in the pioglitazone than the control group during the follow-up. Conclusions: Pioglitazone significantly decreased NIH with increases in circulating microRNA-24 at 9-month followup. The decrease in microRNA-24 could be used as a potential predictor of increases in NIH in type 2 diabetic patients.

Original languageEnglish
Pages (from-to)880-888
Number of pages9
JournalCirculation Journal
Volume79
Issue number4
DOIs
Publication statusPublished - 2015

Keywords

  • Diabetes
  • Endothelial function
  • MicroRNA
  • Pioglitazone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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