Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure

Hoyoun Won, Seok Min Kang, Min-Jeong Shin, Jaewon Oh, Namki Hong, Sungha Park, Sang Hak Lee, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: Plasma adiponectin concentrations are inversely related with metabolic syndrome (MetS), and MetS is associated with increased risk for heart failure (HF). However, the relationship between adiponectin and MetS in HF remains undetermined. Therefore, we tested whether MetS was associated with the degree of plasma adiponectin concentrations in HF patients. Materials and Methods: One hundred twenty eight ambulatory HF patients with left ventricular ejection fraction of <50% (80 males, 61.8±11.9 years old) were enrolled for this cross-sectional study. Echocardiographic measurements were performed, and plasma concentrations of adiponectin, lipoproteins, apolipoproteins (apoB, apoA1) and high sensitive C-reactive protein (hsCRP) were measured. Results: Adiponectin concentrations in HF patients with MetS (n=43) were significantly lower than those without MetS (n=85) (9.7±7.0 vs. 15.8±10.9 μg/mL, p=0.001). Higher concentrations of apoB (p=0.017), apoB/A1 ratio (p<0.001), blood urea nitrogen (p=0.034), creatinine (p=0.003), and fasting insulin (p=0.004) were observed in HF patients with MetS compared with those without MetS. In HF patients with MetS, adiponectin concentrations were negatively correlated with hsCRP (r=-0.388, p=0.015) and positively correlated with the ratio of early mitral inflow velocity to early diastolic mitral annular velocity, E/E' (r=0.399, p=0.015). There was a significant trend towards decreased adiponectin concentrations with an increasing number of components of MetS (p for trend=0.012). Conclusion: Our study demonstrated that adiponectin concentrations decreased in HF patients with MetS, and that relationship between adiponectin, inflammation and abnormal diastolic function, possibly leading to the progression of HF.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalYonsei Medical Journal
Volume53
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Adiponectin
Heart Failure
Apolipoproteins B
C-Reactive Protein
Apolipoproteins
Blood Urea Nitrogen
Stroke Volume
Lipoproteins
Fasting
Creatinine
Cross-Sectional Studies
Insulin
Inflammation

Keywords

  • Adiponectin
  • Heart failure
  • Metabolic syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure. / Won, Hoyoun; Kang, Seok Min; Shin, Min-Jeong; Oh, Jaewon; Hong, Namki; Park, Sungha; Lee, Sang Hak; Jang, Yangsoo; Chung, Namsik.

In: Yonsei Medical Journal, Vol. 53, No. 1, 01.01.2012, p. 91-98.

Research output: Contribution to journalArticle

Won, Hoyoun ; Kang, Seok Min ; Shin, Min-Jeong ; Oh, Jaewon ; Hong, Namki ; Park, Sungha ; Lee, Sang Hak ; Jang, Yangsoo ; Chung, Namsik. / Plasma adiponectin concentration and its association with metabolic syndrome in patients with heart failure. In: Yonsei Medical Journal. 2012 ; Vol. 53, No. 1. pp. 91-98.
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AU - Kang, Seok Min

AU - Shin, Min-Jeong

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AU - Hong, Namki

AU - Park, Sungha

AU - Lee, Sang Hak

AU - Jang, Yangsoo

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