Plasma adiponectin elevation in elderly individuals with subsyndromal depression

Hyun-Ghang Jeong, Beom Jun Min, Soo Lim, Tae Hui Kim, Jung Jae Lee, Joon Hyuk Park, Seok Bum Lee, Ji Won Han, Sung Hee Choi, Young Joo Park, Hak Chul Jang, Ki Woong Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Adiponectin, one of the adipokines, has believed to play a role in developing of depression, but the relationship between plasma adiponectin and depressive disorder is still unclear. To investigate the association between plasma adiponectin and depressive disorders, we measured plasma adiponectin concentrations in 785 randomly sampled elderly Koreans including 41 patients with major depressive disorder (MDD), 46 with minor depressive disorder (MnDD), and 61 with subsyndromal depression (SSD). Plasma adiponectin levels were different among the diagnostic groups (. df=. 3, . F=. 4.928, . P=. 0.002). The plasma adiponectin level in the SSD patients was higher than in the non-depressed controls (NC) (12.48. ±. 8.38. μg/ml versus 9.27. ±. 6.21. μg/ml, . P=. 0.001, Tukey's post hoc comparison). However, plasma adiponectin levels in the MnDD and MDD patients were comparable with those found in the NC (. P>. 0.1, Tukey's post hoc comparison). The elevation of plasma adiponectin in the SSD patients remained significant in men (. P=. 0.002, Tukey's post hoc comparison) but not in women. In the subjects without MDD and MnDD, plasma adiponectin level was positively correlated with the Hamilton Depression Rating Scale score (. r=. 0.156, . P<. 0.001) and the Geriatric Depression Scale (. r=. 0.117, . P=. 0.002). When men and women were analyzed separately, these significant correlations were confined to men. Circulating adiponectin concentration may play a role in compensation on process for depressive mood.

Original languageEnglish
Pages (from-to)948-955
Number of pages8
JournalPsychoneuroendocrinology
Volume37
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

Fingerprint

Adiponectin
Depression
Depressive Disorder
Major Depressive Disorder
Adipokines
Geriatrics

Keywords

  • Adiponectin
  • Gender
  • Major depressive disorder
  • Minor depressive disorder
  • Subsyndromal depression

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Cite this

Plasma adiponectin elevation in elderly individuals with subsyndromal depression. / Jeong, Hyun-Ghang; Min, Beom Jun; Lim, Soo; Kim, Tae Hui; Lee, Jung Jae; Park, Joon Hyuk; Lee, Seok Bum; Han, Ji Won; Choi, Sung Hee; Park, Young Joo; Jang, Hak Chul; Kim, Ki Woong.

In: Psychoneuroendocrinology, Vol. 37, No. 7, 01.07.2012, p. 948-955.

Research output: Contribution to journalArticle

Jeong, H-G, Min, BJ, Lim, S, Kim, TH, Lee, JJ, Park, JH, Lee, SB, Han, JW, Choi, SH, Park, YJ, Jang, HC & Kim, KW 2012, 'Plasma adiponectin elevation in elderly individuals with subsyndromal depression', Psychoneuroendocrinology, vol. 37, no. 7, pp. 948-955. https://doi.org/10.1016/j.psyneuen.2011.11.002
Jeong, Hyun-Ghang ; Min, Beom Jun ; Lim, Soo ; Kim, Tae Hui ; Lee, Jung Jae ; Park, Joon Hyuk ; Lee, Seok Bum ; Han, Ji Won ; Choi, Sung Hee ; Park, Young Joo ; Jang, Hak Chul ; Kim, Ki Woong. / Plasma adiponectin elevation in elderly individuals with subsyndromal depression. In: Psychoneuroendocrinology. 2012 ; Vol. 37, No. 7. pp. 948-955.
@article{07c340b6ef624508a299f565c8cec88a,
title = "Plasma adiponectin elevation in elderly individuals with subsyndromal depression",
abstract = "Adiponectin, one of the adipokines, has believed to play a role in developing of depression, but the relationship between plasma adiponectin and depressive disorder is still unclear. To investigate the association between plasma adiponectin and depressive disorders, we measured plasma adiponectin concentrations in 785 randomly sampled elderly Koreans including 41 patients with major depressive disorder (MDD), 46 with minor depressive disorder (MnDD), and 61 with subsyndromal depression (SSD). Plasma adiponectin levels were different among the diagnostic groups (. df=. 3, . F=. 4.928, . P=. 0.002). The plasma adiponectin level in the SSD patients was higher than in the non-depressed controls (NC) (12.48. ±. 8.38. μg/ml versus 9.27. ±. 6.21. μg/ml, . P=. 0.001, Tukey's post hoc comparison). However, plasma adiponectin levels in the MnDD and MDD patients were comparable with those found in the NC (. P>. 0.1, Tukey's post hoc comparison). The elevation of plasma adiponectin in the SSD patients remained significant in men (. P=. 0.002, Tukey's post hoc comparison) but not in women. In the subjects without MDD and MnDD, plasma adiponectin level was positively correlated with the Hamilton Depression Rating Scale score (. r=. 0.156, . P<. 0.001) and the Geriatric Depression Scale (. r=. 0.117, . P=. 0.002). When men and women were analyzed separately, these significant correlations were confined to men. Circulating adiponectin concentration may play a role in compensation on process for depressive mood.",
keywords = "Adiponectin, Gender, Major depressive disorder, Minor depressive disorder, Subsyndromal depression",
author = "Hyun-Ghang Jeong and Min, {Beom Jun} and Soo Lim and Kim, {Tae Hui} and Lee, {Jung Jae} and Park, {Joon Hyuk} and Lee, {Seok Bum} and Han, {Ji Won} and Choi, {Sung Hee} and Park, {Young Joo} and Jang, {Hak Chul} and Kim, {Ki Woong}",
year = "2012",
month = "7",
day = "1",
doi = "10.1016/j.psyneuen.2011.11.002",
language = "English",
volume = "37",
pages = "948--955",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Plasma adiponectin elevation in elderly individuals with subsyndromal depression

AU - Jeong, Hyun-Ghang

AU - Min, Beom Jun

AU - Lim, Soo

AU - Kim, Tae Hui

AU - Lee, Jung Jae

AU - Park, Joon Hyuk

AU - Lee, Seok Bum

AU - Han, Ji Won

AU - Choi, Sung Hee

AU - Park, Young Joo

AU - Jang, Hak Chul

AU - Kim, Ki Woong

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Adiponectin, one of the adipokines, has believed to play a role in developing of depression, but the relationship between plasma adiponectin and depressive disorder is still unclear. To investigate the association between plasma adiponectin and depressive disorders, we measured plasma adiponectin concentrations in 785 randomly sampled elderly Koreans including 41 patients with major depressive disorder (MDD), 46 with minor depressive disorder (MnDD), and 61 with subsyndromal depression (SSD). Plasma adiponectin levels were different among the diagnostic groups (. df=. 3, . F=. 4.928, . P=. 0.002). The plasma adiponectin level in the SSD patients was higher than in the non-depressed controls (NC) (12.48. ±. 8.38. μg/ml versus 9.27. ±. 6.21. μg/ml, . P=. 0.001, Tukey's post hoc comparison). However, plasma adiponectin levels in the MnDD and MDD patients were comparable with those found in the NC (. P>. 0.1, Tukey's post hoc comparison). The elevation of plasma adiponectin in the SSD patients remained significant in men (. P=. 0.002, Tukey's post hoc comparison) but not in women. In the subjects without MDD and MnDD, plasma adiponectin level was positively correlated with the Hamilton Depression Rating Scale score (. r=. 0.156, . P<. 0.001) and the Geriatric Depression Scale (. r=. 0.117, . P=. 0.002). When men and women were analyzed separately, these significant correlations were confined to men. Circulating adiponectin concentration may play a role in compensation on process for depressive mood.

AB - Adiponectin, one of the adipokines, has believed to play a role in developing of depression, but the relationship between plasma adiponectin and depressive disorder is still unclear. To investigate the association between plasma adiponectin and depressive disorders, we measured plasma adiponectin concentrations in 785 randomly sampled elderly Koreans including 41 patients with major depressive disorder (MDD), 46 with minor depressive disorder (MnDD), and 61 with subsyndromal depression (SSD). Plasma adiponectin levels were different among the diagnostic groups (. df=. 3, . F=. 4.928, . P=. 0.002). The plasma adiponectin level in the SSD patients was higher than in the non-depressed controls (NC) (12.48. ±. 8.38. μg/ml versus 9.27. ±. 6.21. μg/ml, . P=. 0.001, Tukey's post hoc comparison). However, plasma adiponectin levels in the MnDD and MDD patients were comparable with those found in the NC (. P>. 0.1, Tukey's post hoc comparison). The elevation of plasma adiponectin in the SSD patients remained significant in men (. P=. 0.002, Tukey's post hoc comparison) but not in women. In the subjects without MDD and MnDD, plasma adiponectin level was positively correlated with the Hamilton Depression Rating Scale score (. r=. 0.156, . P<. 0.001) and the Geriatric Depression Scale (. r=. 0.117, . P=. 0.002). When men and women were analyzed separately, these significant correlations were confined to men. Circulating adiponectin concentration may play a role in compensation on process for depressive mood.

KW - Adiponectin

KW - Gender

KW - Major depressive disorder

KW - Minor depressive disorder

KW - Subsyndromal depression

UR - http://www.scopus.com/inward/record.url?scp=84861192049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861192049&partnerID=8YFLogxK

U2 - 10.1016/j.psyneuen.2011.11.002

DO - 10.1016/j.psyneuen.2011.11.002

M3 - Article

VL - 37

SP - 948

EP - 955

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

IS - 7

ER -