Plasma ATG5 is increased in Alzheimer’s disease

Sun Jung Cho, Hyun Joung Lim, Chulman Jo, Moon Ho Park, Changsu Han, Young Ho Koh

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Alzheimer’s disease (AD) is a major cause of dementia. Growing evidence suggests that dysregulation of autophagy, a cellular mechanism essential for self-digestion of damaged proteins and organelles, is involved in neurological degenerative diseases including AD. Previously, we reported that autophagosomes are increased in the brains of AD mouse model. However, the plasma levels of autophagic markers have not yet been investigated in patients with AD. In this study, we investigated the expression of autophagy-related genes 5 and 12 (ATG5 and ATG12, respectively) in cells in vitro upon amyloid-beta (Aβ) treatment and in the plasma of AD patients. ATG5-ATG12 complex levels were increased in primary rat cortical neurons and human umbilical vein endothelial cells after Aβ treatment. Furthermore, we compared plasma from 69 patients with dementia, 82 patients with mild cognitive impairment (MCI), and 127 cognitively normal control participants. Plasma levels of ATG5 were significantly elevated in patients with dementia (149.3 ± 7.5 ng/mL) or MCI (152.9 ± 6.9 ng/mL) compared with the control subjects (129.0 ± 4.1 ng/mL) (p = 0.034, p = 0.016, respectively). Our results indicate that alterations in the plasma ATG5 levels might be a potential biomarker in patients at risk for AD.

    Original languageEnglish
    Article number4741
    JournalScientific reports
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - 2019 Dec 1

    ASJC Scopus subject areas

    • General

    Fingerprint

    Dive into the research topics of 'Plasma ATG5 is increased in Alzheimer’s disease'. Together they form a unique fingerprint.

    Cite this