Plasma carbonic anhydrase II protein is elevated in Alzheimer's disease

Bong Geom Jang, Sang Moon Yun, Kyungsook Ahn, Ju Hee Song, Sangmee A. Jo, Young Yul Kim, Doh Kwan Kim, Moon Ho Park, Changsu Han, Young Ho Koh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalJournal of Alzheimer's Disease
Volume21
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • Alzheimer's disease
  • carbonic anhydrase II
  • mild cognitive impairment
  • plasma

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Plasma carbonic anhydrase II protein is elevated in Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this

    Jang, B. G., Yun, S. M., Ahn, K., Song, J. H., Jo, S. A., Kim, Y. Y., Kim, D. K., Park, M. H., Han, C., & Koh, Y. H. (2010). Plasma carbonic anhydrase II protein is elevated in Alzheimer's disease. Journal of Alzheimer's Disease, 21(3), 939-945. https://doi.org/10.3233/JAD-2010-100384