Plasma ceruloplasmin as a biomarker for obesity: A proteomic approach

Oh Yoen Kim, Min Jeong Shin, Jiyoung Moon, Ji Hyung Chung

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objectives: This study aimed to investigate new biomarkers of obesity particularly in relation with inflammation-associated proteins using protein differential display techniques. Design and methods: Comparison of protein expression in plasma between non-obese (n=109, body mass index, BMI<25kg/m2) and obese (n=32, BMI<25kg/m2) groups was carried out using two-dimensional gel electrophoresis (2-DE) analysis. ELISA was also performed for validation. Results: Among six differentially expressed protein spots, ceruloplasmin (Cp) and fibrinogen were over-expressed in obese group. Plasma Cp levels were significantly higher in obese group than non-obese group (34.0 ± 8.6 vs. 41.3 ± 12.7. mg/dL, p< 0.001) and positively correlated with age (r = 0.253, p< 0.005), BMI (r = 0.265, p< 0.001) and hsCRP (r = 0.385, p< 0.001). In stepwise multiple linear regression analysis, plasma Cp along with hsCRP were found predictors for obesity (adjusted β-coefficient. = 0.266, p< 0.01). Conclusion: Elevated plasma Cp levels were significantly associated with obesity, which may be suggested to be a marker of obesity.

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalClinical Biochemistry
Volume44
Issue number5-6
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • Biomarker
  • Ceruloplasmin
  • Obesity
  • Proteomics
  • Two-dimensional gel electrophoresis

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Plasma ceruloplasmin as a biomarker for obesity: A proteomic approach'. Together they form a unique fingerprint.

  • Cite this