Plasma concentration of soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in type 2 diabetic patients, and sICAM-1 synthesis is associated with leptin-induced activation of the mitogen-activated protein kinase (MAPK) pathway

Jin Joo Cha, Young Youl Hyun, Yi Hwa Jee, Mi Jin Lee, Kum Hyun Han, Young Sun Kang, Sang Youb Han, Dae Ryong Cha

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The intercellular adhesion molecule-1 (ICAM-1) and leptin are important inflammatory biomarkers. We investigated whether plasma-soluble ICAM-1 levels were related to the diabetic nephropathy and systemic inflammation. One hundred forty-seven type 2 diabetic patients and 46 healthy control subjects were studied. Plasma sICAM-1 concentrations were significantly higher in the diabetic groups than controls and increased significantly as diabetic nephropathy advanced. Plasma sICAM-1 levels were positively correlated with body mass index, fasting and postprandial blood glucose, urinary albumin excretion, and negatively correlated with creatinine clearance. Multiple regression analysis showed that plasma leptin levels were associated with a significant increase in plasma sICAM-1 levels. In cultured HUVECs, leptin increased ICAM-1 production in a dose-dependent manner, and this stimulating effect of leptin on ICAM-1 expression was reversed by MEK inhibitor, PD98059. Overall, these findings suggest that activation of leptin synthesis in a diabetic environment promotes ICAM-1 activation via mitogen-activated protein kinase pathway in type 2 diabetic patients.

Original languageEnglish
Pages (from-to)878-887
Number of pages10
JournalInflammation
Volume36
Issue number4
DOIs
Publication statusPublished - 2013 Aug

Keywords

  • HUVECs
  • ICAM-1
  • diabetic nephropathy
  • leptin
  • type 2 diabetic patients

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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