Plasma glucose regulation and mortality in Korea: A pooled analysis of three community-based cohort studies

Nan Hee Kim, Dong Jun Kim, Seok Won Park, Jee Young Oh, Joong Yeol Park, Chol Shin, Hong Kyu Lee, Yongsoo Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Although diabetes is a well-known risk factor for death, its impact on cancer death is not clearly understood. Furthermore, it remains controversial whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality. We investigated the impact of diabetes or glucose tolerance categories on all cause and cause-specific mortality. Methods: Mortality analysis was conducted in three population-based cohort studies of 3,801 participants, divided according to fasting plasma glucose (FPG) (normal; stage 1 IFG [5.6<FPG≤6.1 mmol/L]; stage 2 IFG [6.1<FPG≤7.0 mmol/L]; diabetes mellitus [DM]-FPG); or 2-hour glucose after 75 g glucose loading (2hPG) (normal; IGT; DM-2hPG), or a combination of FPG and 2hPG criteria. Results: During a median follow-up of 11.0 years, 474 subjects died from all causes. Hazard ratios (HRs) for all cause death were higher in those with diabetes as defined by either FPG or 2hPG criteria than their normal counterparts (HR, 2.2, 95% confidence interval [CI], 1.6 to 2.9 for DM-FPG; HR, 2.0, 95% CI, 1.5 to 2.7 for DM-2hPG). Similarly, diabetes defined by either FPG or 2hPG was associated with cancer death (HR, 2.9, 95% CI, 1.7 to 5.0; and HR, 2.1, 95% CI, 1.2 to 3.9, respectively). Although neither IFG nor IGT conferred higher risk for death, when combining stage 2 IFG and/or IGT, the risk of all cause death was higher than in subjects with normal glucose regulation (HR, 1.3; 95% CI, 1.0 to 1.6). Conclusion: Diabetes is associated with higher risk of death from all causes and cancer. In subjects without diabetes, stage 2 IFG and/or IGT confers increased risk for mortality.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalDiabetes and Metabolism Journal
Volume38
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Korea
Cohort Studies
Glucose
Fasting
Mortality
Glucose Intolerance
Confidence Intervals
Diabetes Mellitus
Cause of Death
Neoplasms

Keywords

  • Diabetes mellitus
  • Glucose intolerance
  • Mortality

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma glucose regulation and mortality in Korea : A pooled analysis of three community-based cohort studies. / Kim, Nan Hee; Kim, Dong Jun; Park, Seok Won; Oh, Jee Young; Park, Joong Yeol; Shin, Chol; Lee, Hong Kyu; Park, Yongsoo.

In: Diabetes and Metabolism Journal, Vol. 38, No. 1, 01.01.2014, p. 44-50.

Research output: Contribution to journalArticle

Kim, Nan Hee ; Kim, Dong Jun ; Park, Seok Won ; Oh, Jee Young ; Park, Joong Yeol ; Shin, Chol ; Lee, Hong Kyu ; Park, Yongsoo. / Plasma glucose regulation and mortality in Korea : A pooled analysis of three community-based cohort studies. In: Diabetes and Metabolism Journal. 2014 ; Vol. 38, No. 1. pp. 44-50.
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abstract = "Background: Although diabetes is a well-known risk factor for death, its impact on cancer death is not clearly understood. Furthermore, it remains controversial whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality. We investigated the impact of diabetes or glucose tolerance categories on all cause and cause-specific mortality. Methods: Mortality analysis was conducted in three population-based cohort studies of 3,801 participants, divided according to fasting plasma glucose (FPG) (normal; stage 1 IFG [5.6<FPG≤6.1 mmol/L]; stage 2 IFG [6.1<FPG≤7.0 mmol/L]; diabetes mellitus [DM]-FPG); or 2-hour glucose after 75 g glucose loading (2hPG) (normal; IGT; DM-2hPG), or a combination of FPG and 2hPG criteria. Results: During a median follow-up of 11.0 years, 474 subjects died from all causes. Hazard ratios (HRs) for all cause death were higher in those with diabetes as defined by either FPG or 2hPG criteria than their normal counterparts (HR, 2.2, 95{\%} confidence interval [CI], 1.6 to 2.9 for DM-FPG; HR, 2.0, 95{\%} CI, 1.5 to 2.7 for DM-2hPG). Similarly, diabetes defined by either FPG or 2hPG was associated with cancer death (HR, 2.9, 95{\%} CI, 1.7 to 5.0; and HR, 2.1, 95{\%} CI, 1.2 to 3.9, respectively). Although neither IFG nor IGT conferred higher risk for death, when combining stage 2 IFG and/or IGT, the risk of all cause death was higher than in subjects with normal glucose regulation (HR, 1.3; 95{\%} CI, 1.0 to 1.6). Conclusion: Diabetes is associated with higher risk of death from all causes and cancer. In subjects without diabetes, stage 2 IFG and/or IGT confers increased risk for mortality.",
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T2 - A pooled analysis of three community-based cohort studies

AU - Kim, Nan Hee

AU - Kim, Dong Jun

AU - Park, Seok Won

AU - Oh, Jee Young

AU - Park, Joong Yeol

AU - Shin, Chol

AU - Lee, Hong Kyu

AU - Park, Yongsoo

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N2 - Background: Although diabetes is a well-known risk factor for death, its impact on cancer death is not clearly understood. Furthermore, it remains controversial whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality. We investigated the impact of diabetes or glucose tolerance categories on all cause and cause-specific mortality. Methods: Mortality analysis was conducted in three population-based cohort studies of 3,801 participants, divided according to fasting plasma glucose (FPG) (normal; stage 1 IFG [5.6<FPG≤6.1 mmol/L]; stage 2 IFG [6.1<FPG≤7.0 mmol/L]; diabetes mellitus [DM]-FPG); or 2-hour glucose after 75 g glucose loading (2hPG) (normal; IGT; DM-2hPG), or a combination of FPG and 2hPG criteria. Results: During a median follow-up of 11.0 years, 474 subjects died from all causes. Hazard ratios (HRs) for all cause death were higher in those with diabetes as defined by either FPG or 2hPG criteria than their normal counterparts (HR, 2.2, 95% confidence interval [CI], 1.6 to 2.9 for DM-FPG; HR, 2.0, 95% CI, 1.5 to 2.7 for DM-2hPG). Similarly, diabetes defined by either FPG or 2hPG was associated with cancer death (HR, 2.9, 95% CI, 1.7 to 5.0; and HR, 2.1, 95% CI, 1.2 to 3.9, respectively). Although neither IFG nor IGT conferred higher risk for death, when combining stage 2 IFG and/or IGT, the risk of all cause death was higher than in subjects with normal glucose regulation (HR, 1.3; 95% CI, 1.0 to 1.6). Conclusion: Diabetes is associated with higher risk of death from all causes and cancer. In subjects without diabetes, stage 2 IFG and/or IGT confers increased risk for mortality.

AB - Background: Although diabetes is a well-known risk factor for death, its impact on cancer death is not clearly understood. Furthermore, it remains controversial whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality. We investigated the impact of diabetes or glucose tolerance categories on all cause and cause-specific mortality. Methods: Mortality analysis was conducted in three population-based cohort studies of 3,801 participants, divided according to fasting plasma glucose (FPG) (normal; stage 1 IFG [5.6<FPG≤6.1 mmol/L]; stage 2 IFG [6.1<FPG≤7.0 mmol/L]; diabetes mellitus [DM]-FPG); or 2-hour glucose after 75 g glucose loading (2hPG) (normal; IGT; DM-2hPG), or a combination of FPG and 2hPG criteria. Results: During a median follow-up of 11.0 years, 474 subjects died from all causes. Hazard ratios (HRs) for all cause death were higher in those with diabetes as defined by either FPG or 2hPG criteria than their normal counterparts (HR, 2.2, 95% confidence interval [CI], 1.6 to 2.9 for DM-FPG; HR, 2.0, 95% CI, 1.5 to 2.7 for DM-2hPG). Similarly, diabetes defined by either FPG or 2hPG was associated with cancer death (HR, 2.9, 95% CI, 1.7 to 5.0; and HR, 2.1, 95% CI, 1.2 to 3.9, respectively). Although neither IFG nor IGT conferred higher risk for death, when combining stage 2 IFG and/or IGT, the risk of all cause death was higher than in subjects with normal glucose regulation (HR, 1.3; 95% CI, 1.0 to 1.6). Conclusion: Diabetes is associated with higher risk of death from all causes and cancer. In subjects without diabetes, stage 2 IFG and/or IGT confers increased risk for mortality.

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