Plasma glucose regulation and mortality in Pima Indians

Nan Hee Kim, Meda E. Pavkov, Helen C. Looker, Robert G. Nelson, Peter H. Bennett, Robert L. Hanson, Jeffrey M. Curtis, Maurice L. Sievers, William C. Knowler

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - To evaluate whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality and prevalent ischemic heart disease (IHD) and to analyze if the increased risk of death is dependent on subsequent development of diabetes in Pima Indians. RESEARCH DESION AND METHODS - A total of 2,993 Pima Indians aged ≥35 years were included. Prevalent IHD, defined by major ischemic electrocardiogram changes, was evaluated according to the following glucose/diabetes categories: normal glucose regulation (NGR), IFG and/or IGT, and diabetic groups by duration. During a median follow-up of 10.4 years, 780 subjects died from natural causes and 156 of these died from IHD. Mortality was analyzed according to the same glucose/diabetes categories at baseline and then as time-dependent variables. RESULTS - Only subjects with diabetes 3:15 years of duration have a higher prevalence of IHD (odds ratio 1.9 [95% CI 1.4-2.5]) relative to NGR. In baseline and time-dependent models, age- and sex-adjusted death rates from natural causes and from IHD were similar among the nondiabetic groups. Among diabetic subjects, natural mortality was higher in those with 3:15 years diabetes duration (death rate ratio [DRR] relative to NGR = 2.6 [95% CI 2.1-3.3]). IHD mortality was higher in subjects with long diabetes duration (DRR for diabetes 10-15 years = 3.8 [1.5-9.5]; DRR for diabetes ≥15 years = 8.6 [3.8-19.4]) in the time-dependent model. CONCLUSIONS - Natural and IHD mortality are not increased in Pima Indians with IFG and/or IGT. Only after the onset of diabetes do the rates of these events increase relative to NGR.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalDiabetes Care
Volume31
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1
Externally publishedYes

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Potassium Iodide
Myocardial Ischemia
Glucose
Mortality
Glucose Intolerance
Fasting
Electrocardiography
Odds Ratio

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Kim, N. H., Pavkov, M. E., Looker, H. C., Nelson, R. G., Bennett, P. H., Hanson, R. L., ... Knowler, W. C. (2008). Plasma glucose regulation and mortality in Pima Indians. Diabetes Care, 31(3), 488-492. https://doi.org/10.2337/dc07-1850

Plasma glucose regulation and mortality in Pima Indians. / Kim, Nan Hee; Pavkov, Meda E.; Looker, Helen C.; Nelson, Robert G.; Bennett, Peter H.; Hanson, Robert L.; Curtis, Jeffrey M.; Sievers, Maurice L.; Knowler, William C.

In: Diabetes Care, Vol. 31, No. 3, 01.03.2008, p. 488-492.

Research output: Contribution to journalArticle

Kim, NH, Pavkov, ME, Looker, HC, Nelson, RG, Bennett, PH, Hanson, RL, Curtis, JM, Sievers, ML & Knowler, WC 2008, 'Plasma glucose regulation and mortality in Pima Indians', Diabetes Care, vol. 31, no. 3, pp. 488-492. https://doi.org/10.2337/dc07-1850
Kim NH, Pavkov ME, Looker HC, Nelson RG, Bennett PH, Hanson RL et al. Plasma glucose regulation and mortality in Pima Indians. Diabetes Care. 2008 Mar 1;31(3):488-492. https://doi.org/10.2337/dc07-1850
Kim, Nan Hee ; Pavkov, Meda E. ; Looker, Helen C. ; Nelson, Robert G. ; Bennett, Peter H. ; Hanson, Robert L. ; Curtis, Jeffrey M. ; Sievers, Maurice L. ; Knowler, William C. / Plasma glucose regulation and mortality in Pima Indians. In: Diabetes Care. 2008 ; Vol. 31, No. 3. pp. 488-492.
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