Plasma levels of leptin are associated with the plasma levels of LDL conjugated dienes in children

Min Jeong Shin, Eunju Park

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: Plasma leptin has been suggested to be involved in the proatherogenic process by increasing oxidative stress. We investigated the relationship between leptin and plasma conjugated diene formation, a measure of LDL oxidation in vivo in schoolchildren. Methods: We measured blood lipid profiles, plasma antioxidant vitamins, leptin and diene conjugation in LDL of 118 Korean children (35 overweight-obese vs. 83 normal weight children). Results: The overweight-obese children showed significantly higher levels of leptin (p < 0.0001), conjugated dienes (p = 0.02), total cholesterol (p < 0.05), triglyceride (p < 0.005) and LDL cholesterol (p < 0.01) and a significantly lower level of plasma lycopene (p < 0.0001) compared with the normal weight children. When all the subjects were classified into the three groups by tertiles of leptin levels, significant differences in circulating conjugated dienes (p < 0.05), lipid-corrected lycopene (p < 0.05), total cholesterol (p < 0.05), triglyceride (p < 0.05) and LDL cholesterol (p < 0.05) were found among the three groups. Conclusion: Our results showed that leptin was positively associated with the LDL conjugated diene formation, which might be related to the proatherogenic process in schoolchildren.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalAnnals of Nutrition and Metabolism
Volume51
Issue number1
DOIs
Publication statusPublished - 2007 Apr
Externally publishedYes

Keywords

  • Antioxidant vitamins
  • Conjugated diene
  • LDL oxidation
  • Leptin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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