Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

Soo Lee Kang, Hyung Chung Ji, Hye Lee Kyung, Min-Jeong Shin, Hoon Oh Byoung, Hyung Lee Soo, Hyung Hong Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalCellular and Molecular Immunology
Volume6
Issue number2
DOIs
Publication statusPublished - 2009 Apr 1

Fingerprint

Chemokine CCL7
Nerve Growth Factor
Cytokines
Chemokines
Dementia
Blood Proteins
Intercellular Signaling Peptides and Proteins
Cognitive Dysfunction

Keywords

  • Biomarker
  • Cytokine
  • Inflammation
  • Mild cognitive impairment
  • Plasma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment. / Kang, Soo Lee; Ji, Hyung Chung; Kyung, Hye Lee; Shin, Min-Jeong; Byoung, Hoon Oh; Soo, Hyung Lee; Chang, Hyung Hong.

In: Cellular and Molecular Immunology, Vol. 6, No. 2, 01.04.2009, p. 143-147.

Research output: Contribution to journalArticle

Kang, Soo Lee ; Ji, Hyung Chung ; Kyung, Hye Lee ; Shin, Min-Jeong ; Byoung, Hoon Oh ; Soo, Hyung Lee ; Chang, Hyung Hong. / Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment. In: Cellular and Molecular Immunology. 2009 ; Vol. 6, No. 2. pp. 143-147.
@article{a07cb07af4754ab5b4d4bb454337d46f,
title = "Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment",
abstract = "A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.",
keywords = "Biomarker, Cytokine, Inflammation, Mild cognitive impairment, Plasma",
author = "Kang, {Soo Lee} and Ji, {Hyung Chung} and Kyung, {Hye Lee} and Min-Jeong Shin and Byoung, {Hoon Oh} and Soo, {Hyung Lee} and Chang, {Hyung Hong}",
year = "2009",
month = "4",
day = "1",
doi = "10.1038/cmi.2009.20",
language = "English",
volume = "6",
pages = "143--147",
journal = "Cellular and Molecular Immunology",
issn = "1672-7681",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

AU - Kang, Soo Lee

AU - Ji, Hyung Chung

AU - Kyung, Hye Lee

AU - Shin, Min-Jeong

AU - Byoung, Hoon Oh

AU - Soo, Hyung Lee

AU - Chang, Hyung Hong

PY - 2009/4/1

Y1 - 2009/4/1

N2 - A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

AB - A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

KW - Biomarker

KW - Cytokine

KW - Inflammation

KW - Mild cognitive impairment

KW - Plasma

UR - http://www.scopus.com/inward/record.url?scp=68549127011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68549127011&partnerID=8YFLogxK

U2 - 10.1038/cmi.2009.20

DO - 10.1038/cmi.2009.20

M3 - Article

C2 - 19403065

AN - SCOPUS:68549127011

VL - 6

SP - 143

EP - 147

JO - Cellular and Molecular Immunology

JF - Cellular and Molecular Immunology

SN - 1672-7681

IS - 2

ER -