Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

Soo Lee Kang, Hyung Chung Ji, Hye Lee Kyung, Min Jeong Shin, Hoon Oh Byoung, Hyung Lee Soo, Hyung Hong Chang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (β-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and β-NGF may be useful in differentiating subtypes of MCI.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalCellular and Molecular Immunology
Volume6
Issue number2
DOIs
Publication statusPublished - 2009 Apr

Keywords

  • Biomarker
  • Cytokine
  • Inflammation
  • Mild cognitive impairment
  • Plasma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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