Plasma phospholipid arachidonic acid and lignoceric acid are associated with the risk of cardioembolic stroke

Hye Kyung Chung, Yoonsu Cho, Hyun Ju Do, Kyungmi Oh, Woo Keun Seo, Min-Jeong Shin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cardioembolic (CE) stroke is the most severe subtype of ischemic stroke with high recurrence and mortality. However, there is still little information on the association of plasma fatty acid (FA) with CE stroke. The objective of this study was to test the hypothesis whether the composition of plasma phospholipid FA is associated with the risk of CE stroke. The study subjects were collected from the Korea University Stroke Registry. Twenty-one subjects were selected as CE stroke group, and 39 age-and sex-matched subjects with non-CE stroke were selected as controls. Sociodemographic factors, clinical measurements, and plasma phospholipid FA compositions were compared between the groups. Logistic regression was used to obtain estimates of the associations between the relevant FAs and CE stroke. The result showed that the CE stroke group had higher levels of free FA and lower levels of triglycerides before and after adjustment (all P <.05). In the regression analysis, elaidic acid (18:1Tn9) and arachidonic acid (20:4n6) were positively related, but lignoceric acid (24:0) was negatively related to CE stroke in all constructed models (all P <.05). In conclusion, plasma phospholipid FA composition was associated with CE stroke risk in Korean population, with higher proportions of elaidic acid and arachidonic acid and lower proportion of lignoceric acid in CE stroke.

Original languageEnglish
Pages (from-to)1001-1008
Number of pages8
JournalNutrition Research
Volume35
Issue number11
DOIs
Publication statusPublished - 2015

Keywords

  • Arachidonic acid
  • Cardioembolic stroke
  • Fatty acid
  • Lignoceric acid
  • Trans-fat

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Plasma phospholipid arachidonic acid and lignoceric acid are associated with the risk of cardioembolic stroke'. Together they form a unique fingerprint.

  • Cite this