Abstract
Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.
| Original language | English |
|---|---|
| Pages (from-to) | 418-424 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 225 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
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Keywords
- Docosahexaenoic acid
- Fatty acid
- Intracranial atherosclerotic stenosis
- Ischemic stroke
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Plasma phospholipid fatty acid composition in ischemic stroke : Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. / Kim, Yong Jae; Kim, Oh Yoen; Cho, Yoonsu; Chung, Ji Hyung; Jung, Young Sang; Hwang, Geum Sook; Shin, Min-Jeong.
In: Atherosclerosis, Vol. 225, No. 2, 01.12.2012, p. 418-424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma phospholipid fatty acid composition in ischemic stroke
T2 - Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis
AU - Kim, Yong Jae
AU - Kim, Oh Yoen
AU - Cho, Yoonsu
AU - Chung, Ji Hyung
AU - Jung, Young Sang
AU - Hwang, Geum Sook
AU - Shin, Min-Jeong
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.
AB - Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.
KW - Docosahexaenoic acid
KW - Fatty acid
KW - Intracranial atherosclerotic stenosis
KW - Ischemic stroke
UR - http://www.scopus.com/inward/record.url?scp=84869507004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869507004&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2012.09.007
DO - 10.1016/j.atherosclerosis.2012.09.007
M3 - Article
C2 - 23044095
AN - SCOPUS:84869507004
VL - 225
SP - 418
EP - 424
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -