Plasma phospholipid fatty acid composition in ischemic stroke: Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis

Yong Jae Kim, Oh Yoen Kim, Yoonsu Cho, Ji Hyung Chung, Young Sang Jung, Geum Sook Hwang, Min-Jeong Shin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalAtherosclerosis
Volume225
Issue number2
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Docosahexaenoic Acids
Phospholipids
Pathologic Constriction
Fatty Acids
Stroke
Eicosapentaenoic Acid
Diet
Hypertension

Keywords

  • Docosahexaenoic acid
  • Fatty acid
  • Intracranial atherosclerotic stenosis
  • Ischemic stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plasma phospholipid fatty acid composition in ischemic stroke : Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. / Kim, Yong Jae; Kim, Oh Yoen; Cho, Yoonsu; Chung, Ji Hyung; Jung, Young Sang; Hwang, Geum Sook; Shin, Min-Jeong.

In: Atherosclerosis, Vol. 225, No. 2, 01.12.2012, p. 418-424.

Research output: Contribution to journalArticle

Kim, Yong Jae ; Kim, Oh Yoen ; Cho, Yoonsu ; Chung, Ji Hyung ; Jung, Young Sang ; Hwang, Geum Sook ; Shin, Min-Jeong. / Plasma phospholipid fatty acid composition in ischemic stroke : Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis. In: Atherosclerosis. 2012 ; Vol. 225, No. 2. pp. 418-424.
@article{abfb64c49cff437fb280fccba59cedf2,
title = "Plasma phospholipid fatty acid composition in ischemic stroke: Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis",
abstract = "Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95{\%} CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.",
keywords = "Docosahexaenoic acid, Fatty acid, Intracranial atherosclerotic stenosis, Ischemic stroke",
author = "Kim, {Yong Jae} and Kim, {Oh Yoen} and Yoonsu Cho and Chung, {Ji Hyung} and Jung, {Young Sang} and Hwang, {Geum Sook} and Min-Jeong Shin",
year = "2012",
month = "12",
day = "1",
doi = "10.1016/j.atherosclerosis.2012.09.007",
language = "English",
volume = "225",
pages = "418--424",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Plasma phospholipid fatty acid composition in ischemic stroke

T2 - Importance of docosahexaenoic acid in the risk for intracranial atherosclerotic stenosis

AU - Kim, Yong Jae

AU - Kim, Oh Yoen

AU - Cho, Yoonsu

AU - Chung, Ji Hyung

AU - Jung, Young Sang

AU - Hwang, Geum Sook

AU - Shin, Min-Jeong

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.

AB - Objective: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. Methods: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. Results: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. Conclusion: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.

KW - Docosahexaenoic acid

KW - Fatty acid

KW - Intracranial atherosclerotic stenosis

KW - Ischemic stroke

UR - http://www.scopus.com/inward/record.url?scp=84869507004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869507004&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2012.09.007

DO - 10.1016/j.atherosclerosis.2012.09.007

M3 - Article

C2 - 23044095

AN - SCOPUS:84869507004

VL - 225

SP - 418

EP - 424

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -